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Molecular dynamics in drug design: new generations of compstatin analogs.
Tamamis P, López de Victoria A, Gorham RD Jr, Bellows-Peterson ML, Pierou P, Floudas CA, Morikis D, Archontis G. Tamamis P, et al. Among authors: archontis g. Chem Biol Drug Des. 2012 May;79(5):703-18. doi: 10.1111/j.1747-0285.2012.01324.x. Epub 2012 Feb 9. Chem Biol Drug Des. 2012. PMID: 22233517 Free PMC article.
Novel compstatin family peptides inhibit complement activation by drusen-like deposits in human retinal pigmented epithelial cell cultures.
Gorham RD Jr, Forest DL, Tamamis P, López de Victoria A, Kraszni M, Kieslich CA, Banna CD, Bellows-Peterson ML, Larive CK, Floudas CA, Archontis G, Johnson LV, Morikis D. Gorham RD Jr, et al. Among authors: archontis g. Exp Eye Res. 2013 Nov;116:96-108. doi: 10.1016/j.exer.2013.07.023. Epub 2013 Aug 15. Exp Eye Res. 2013. PMID: 23954241 Free PMC article.
New compstatin peptides containing N-terminal extensions and non-natural amino acids exhibit potent complement inhibition and improved solubility characteristics.
Gorham RD Jr, Forest DL, Khoury GA, Smadbeck J, Beecher CN, Healy ED, Tamamis P, Archontis G, Larive CK, Floudas CA, Radeke MJ, Johnson LV, Morikis D. Gorham RD Jr, et al. Among authors: archontis g. J Med Chem. 2015 Jan 22;58(2):814-26. doi: 10.1021/jm501345y. Epub 2014 Dec 29. J Med Chem. 2015. PMID: 25494040 Free PMC article.
47 results