Choi JY - Search Results

1

Structure guided development of novel thymidine mimetics targeting Pseudomonas aeruginosa thymidylate kinase: from hit to lead generation.

Choi JY, Plummer MS, Starr J, Desbonnet CR, Soutter H, Chang J, Miller JR, Dillman K, Miller AA, Roush WR. Choi JY, et al. J Med Chem. 2012 Jan 26;55(2):852-70. doi: 10.1021/jm201349f. Epub 2012 Jan 13. J Med Chem. 2012. PMID: 22243413 Free PMC article.

2

Chemistry and biology of macrolide antiparasitic agents.

Lee Y, Choi JY, Fu H, Harvey C, Ravindran S, Roush WR, Boothroyd JC, Khosla C. Lee Y, et al. Among authors: choi jy. J Med Chem. 2011 Apr 28;54(8):2792-804. doi: 10.1021/jm101593u. Epub 2011 Mar 23. J Med Chem. 2011. PMID: 21428405 Free PMC article.

3

Development of highly selective casein kinase 1δ/1ε (CK1δ/ε) inhibitors with potent antiproliferative properties.

Bibian M, Rahaim RJ, Choi JY, Noguchi Y, Schürer S, Chen W, Nakanishi S, Licht K, Rosenberg LH, Li L, Feng Y, Cameron MD, Duckett DR, Cleveland JL, Roush WR. Bibian M, et al. Among authors: choi jy. Bioorg Med Chem Lett. 2013 Aug 1;23(15):4374-80. doi: 10.1016/j.bmcl.2013.05.075. Epub 2013 May 31. Bioorg Med Chem Lett. 2013. PMID: 23787102 Free PMC article.

4

Rational development of 4-aminopyridyl-based inhibitors targeting Trypanosoma cruzi CYP51 as anti-chagas agents.

Choi JY, Calvet CM, Gunatilleke SS, Ruiz C, Cameron MD, McKerrow JH, Podust LM, Roush WR. Choi JY, et al. J Med Chem. 2013 Oct 10;56(19):7651-68. doi: 10.1021/jm401067s. Epub 2013 Sep 30. J Med Chem. 2013. PMID: 24079662 Free PMC article.

5

Expanding the binding envelope of CYP51 inhibitors targeting Trypanosoma cruzi with 4-aminopyridyl-based sulfonamide derivatives.

Vieira DF, Choi JY, Roush WR, Podust LM. Vieira DF, et al. Among authors: choi jy. Chembiochem. 2014 May 26;15(8):1111-20. doi: 10.1002/cbic.201402027. Epub 2014 Apr 25. Chembiochem. 2014. PMID: 24771705 Free PMC article.

6

R-Configuration of 4-Aminopyridyl-Based Inhibitors of CYP51 Confers Superior Efficacy Against Trypanosoma cruzi.

Choi JY, Calvet CM, Vieira DF, Gunatilleke SS, Cameron MD, McKerrow JH, Podust LM, Roush WR. Choi JY, et al. ACS Med Chem Lett. 2014 Jan 22;5(4):434-9. doi: 10.1021/ml500010m. eCollection 2014 Apr 10. ACS Med Chem Lett. 2014. PMID: 24900854 Free PMC article.

7

4-Aminopyridyl-based CYP51 inhibitors as anti-Trypanosoma cruzi drug leads with improved pharmacokinetic profile and in vivo potency.

Calvet CM, Vieira DF, Choi JY, Kellar D, Cameron MD, Siqueira-Neto JL, Gut J, Johnston JB, Lin L, Khan S, McKerrow JH, Roush WR, Podust LM. Calvet CM, et al. Among authors: choi jy. J Med Chem. 2014 Aug 28;57(16):6989-7005. doi: 10.1021/jm500448u. Epub 2014 Aug 19. J Med Chem. 2014. PMID: 25101801 Free PMC article.

8

Characterization of selective exosite-binding inhibitors of matrix metalloproteinase 13 that prevent articular cartilage degradation in vitro.

Spicer TP, Jiang J, Taylor AB, Choi JY, Hart PJ, Roush WR, Fields GB, Hodder PS, Minond D. Spicer TP, et al. Among authors: choi jy. J Med Chem. 2014 Nov 26;57(22):9598-611. doi: 10.1021/jm501284e. Epub 2014 Nov 11. J Med Chem. 2014. PMID: 25330343 Free PMC article.

9

Drug strategies targeting CYP51 in neglected tropical diseases.

Choi JY, Podust LM, Roush WR. Choi JY, et al. Chem Rev. 2014 Nov 26;114(22):11242-71. doi: 10.1021/cr5003134. Epub 2014 Oct 22. Chem Rev. 2014. PMID: 25337991 Free PMC article. Review. No abstract available.

10

Binding mode and potency of N-indolyloxopyridinyl-4-aminopropanyl-based inhibitors targeting Trypanosoma cruzi CYP51.

Vieira DF, Choi JY, Calvet CM, Siqueira-Neto JL, Johnston JB, Kellar D, Gut J, Cameron MD, McKerrow JH, Roush WR, Podust LM. Vieira DF, et al. Among authors: choi jy. J Med Chem. 2014 Dec 11;57(23):10162-75. doi: 10.1021/jm501568b. Epub 2014 Nov 25. J Med Chem. 2014. PMID: 25393646 Free PMC article.

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