Chen L - Search Results

1

Effect of KRAS oncogene substitutions on protein behavior: implications for signaling and clinical outcome.

Ihle NT, Byers LA, Kim ES, Saintigny P, Lee JJ, Blumenschein GR, Tsao A, Liu S, Larsen JE, Wang J, Diao L, Coombes KR, Chen L, Zhang S, Abdelmelek MF, Tang X, Papadimitrakopoulou V, Minna JD, Lippman SM, Hong WK, Herbst RS, Wistuba II, Heymach JV, Powis G. Ihle NT, et al. Among authors: chen l. J Natl Cancer Inst. 2012 Feb 8;104(3):228-39. doi: 10.1093/jnci/djr523. Epub 2012 Jan 13. J Natl Cancer Inst. 2012. PMID: 22247021 Free PMC article.

2

Recent development of anticancer therapeutics targeting Akt.

Morrow JK, Du-Cuny L, Chen L, Meuillet EJ, Mash EA, Powis G, Zhang S. Morrow JK, et al. Among authors: chen l. Recent Pat Anticancer Drug Discov. 2011 Jan;6(1):146-59. doi: 10.2174/157489211793980079. Recent Pat Anticancer Drug Discov. 2011. PMID: 21110830 Free PMC article. Review.

3

Comprehensive Modeling and Discovery of Mebendazole as a Novel TRAF2- and NCK-interacting Kinase Inhibitor.

Tan Z, Chen L, Zhang S. Tan Z, et al. Among authors: chen l. Sci Rep. 2016 Sep 21;6:33534. doi: 10.1038/srep33534. Sci Rep. 2016. PMID: 27650168 Free PMC article.

4

Novel insights of structure-based modeling for RNA-targeted drug discovery.

Chen L, Calin GA, Zhang S. Chen L, et al. J Chem Inf Model. 2012 Oct 22;52(10):2741-53. doi: 10.1021/ci300320t. Epub 2012 Sep 21. J Chem Inf Model. 2012. PMID: 22947071 Free PMC article.

5

Small molecule compounds targeting miRNAs for cancer therapy.

Monroig Pdel C, Chen L, Zhang S, Calin GA. Monroig Pdel C, et al. Among authors: chen l. Adv Drug Deliv Rev. 2015 Jan;81:104-16. doi: 10.1016/j.addr.2014.09.002. Epub 2014 Sep 17. Adv Drug Deliv Rev. 2015. PMID: 25239236 Free PMC article. Review.

6

A critical assessment of combined ligand- and structure-based approaches to HERG channel blocker modeling.

Du-Cuny L, Chen L, Zhang S. Du-Cuny L, et al. Among authors: chen l. J Chem Inf Model. 2011 Nov 28;51(11):2948-60. doi: 10.1021/ci200271d. Epub 2011 Oct 13. J Chem Inf Model. 2011. PMID: 21902220 Free PMC article.

7

From laptop to benchtop to bedside: structure-based drug design on protein targets.

Chen L, Morrow JK, Tran HT, Phatak SS, Du-Cuny L, Zhang S. Chen L, et al. Curr Pharm Des. 2012;18(9):1217-39. doi: 10.2174/138161212799436386. Curr Pharm Des. 2012. PMID: 22316152 Free PMC article. Review.

8

Novel inhibitors induce large conformational changes of GAB1 pleckstrin homology domain and kill breast cancer cells.

Chen L, Du-Cuny L, Moses S, Dumas S, Song Z, Rezaeian AH, Lin HK, Meuillet EJ, Zhang S. Chen L, et al. PLoS Comput Biol. 2015 Jan 8;11(1):e1004021. doi: 10.1371/journal.pcbi.1004021. eCollection 2015 Jan. PLoS Comput Biol. 2015. PMID: 25569504 Free PMC article.

9

2-Amino-1,3-benzothiazole-6-carboxamide Preferentially Binds the Tandem Mismatch Motif r(UY:GA).

Chang AT, Chen L, Song L, Zhang S, Nikonowicz EP. Chang AT, et al. Among authors: chen l. Biochemistry. 2020 Sep 8;59(35):3225-3234. doi: 10.1021/acs.biochem.0c00369. Epub 2020 Aug 20. Biochemistry. 2020. PMID: 32786414

10

Synthesis of a 2(1H)-pyridone library via rhodium-catalyzed formation of isomunchones.

De S, Chen L, Zhang S, Gilbertson SR. De S, et al. Among authors: chen l. ACS Comb Sci. 2013 Jul 8;15(7):340-3. doi: 10.1021/co400067q. Epub 2013 Jun 12. ACS Comb Sci. 2013. PMID: 23742807

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