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Hit to lead evaluation of 1,2,3-triazolo[4,5-b]pyridines as PIM kinase inhibitors.
Pastor J, Oyarzabal J, Saluste G, Alvarez RM, Rivero V, Ramos F, Cendón E, Blanco-Aparicio C, Ajenjo N, Cebriá A, Albarrán MI, Cebrián D, Corrionero A, Fominaya J, Montoya G, Mazzorana M. Pastor J, et al. Bioorg Med Chem Lett. 2012 Feb 15;22(4):1591-7. doi: 10.1016/j.bmcl.2011.12.130. Epub 2012 Jan 5. Bioorg Med Chem Lett. 2012. PMID: 22266039
MAP17 overexpression is a common characteristic of carcinomas.
Guijarro MV, Leal JF, Fominaya J, Blanco-Aparicio C, Alonso S, Lleonart M, Castellvi J, Ruiz L, Ramon Y Cajal S, Carnero A. Guijarro MV, et al. Carcinogenesis. 2007 Aug;28(8):1646-52. doi: 10.1093/carcin/bgm083. Epub 2007 Apr 9. Carcinogenesis. 2007. PMID: 17426052
Pim 1 kinase inhibitor ETP-45299 suppresses cellular proliferation and synergizes with PI3K inhibition.
Blanco-Aparicio C, Collazo AM, Oyarzabal J, Leal JF, Albarán MI, Lima FR, Pequeño B, Ajenjo N, Becerra M, Alfonso P, Reymundo MI, Palacios I, Mateos G, Quiñones H, Corrionero A, Carnero A, Pevarello P, Lopez AR, Fominaya J, Pastor J, Bischoff JR. Blanco-Aparicio C, et al. Cancer Lett. 2011 Jan 28;300(2):145-53. doi: 10.1016/j.canlet.2010.09.016. Epub 2010 Nov 3. Cancer Lett. 2011. PMID: 21051136
Spinophilin acts as a tumor suppressor by regulating Rb phosphorylation.
Ferrer I, Blanco-Aparicio C, Peregrina S, Cañamero M, Fominaya J, Cecilia Y, Lleonart M, Hernandez-Losa J, Ramon y Cajal S, Carnero A. Ferrer I, et al. Cell Cycle. 2011 Aug 15;10(16):2751-62. doi: 10.4161/cc.10.16.16422. Epub 2011 Aug 15. Cell Cycle. 2011. PMID: 21772120 Free article.
The essential role of PIM kinases in sarcoma growth and bone invasion.
Narlik-Grassow M, Blanco-Aparicio C, Cecilia Y, Peregrina S, Garcia-Serelde B, Muñoz-Galvan S, Cañamero M, Carnero A. Narlik-Grassow M, et al. Carcinogenesis. 2012 Aug;33(8):1479-86. doi: 10.1093/carcin/bgs176. Epub 2012 May 22. Carcinogenesis. 2012. PMID: 22623646 Free article.
76 results