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Lipid rafts couple store-operated Ca2+ entry to constitutive activation of PKB/Akt in a Ca2+/calmodulin-, Src- and PP2A-mediated pathway and promote melanoma tumor growth.
Carcinogenesis. 2012 Apr;33(4):740-50. doi: 10.1093/carcin/bgs021. Epub 2012 Jan 27.
Carcinogenesis. 2012.
PMID: 22287561
Amplified lipid rafts of malignant cells constitute a target for inhibition of aberrantly active NFAT and melanoma tumor growth by the aminobisphosphonate zoledronic acid.
Levin-Gromiko U, Koshelev V, Kushnir P, Fedida-Metula S, Voronov E, Fishman D.
Levin-Gromiko U, et al.
Carcinogenesis. 2014 Nov;35(11):2555-66. doi: 10.1093/carcin/bgu178. Epub 2014 Aug 20.
Carcinogenesis. 2014.
PMID: 25142972
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