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The Smac mimetic RMT5265.2HCL induces apoptosis in EBV and HTLV-I associated lymphoma cells by inhibiting XIAP and promoting the mitochondrial release of cytochrome C and Smac.
Ramachandiran S, Cain J, Liao A, He Y, Guo X, Boise LH, Fu H, Ratner L, Khoury HJ, Bernal-Mizrachi L. Ramachandiran S, et al. Among authors: cain j. Leuk Res. 2012 Jun;36(6):784-90. doi: 10.1016/j.leukres.2011.12.024. Epub 2012 Feb 10. Leuk Res. 2012. PMID: 22325366 Free PMC article.
Multidimensional, integrative profiling identifies BCL2L1 methylation as a predictor of MCL1 dependency in pediatric malignancies.
Adjumain S, Daniel P, Sun CX, Bradshaw G, Chew NJ, Tsui V, Lee H, Loi M, Zhukova N, Habarakada D, Yoel A, Vaghjiani VG, Game S, Ludlow LE, Neeman N, Sweet-Cordero EA, Eisenstat DD, Cain JE, Firestein R. Adjumain S, et al. Among authors: cain je. JCI Insight. 2025 Jan 23;10(2):e184601. doi: 10.1172/jci.insight.184601. JCI Insight. 2025. PMID: 39846250
Lung function and onset of cardiometabolic diseases in the longitudinal Burden of Obstructive Lung Disease study.
Janson C, Potts J, Malinovschi A, Agarwal D, Ahmed R, Aquart-Stewart A, Harrabi I, Denguezli M, Devereux G, Erhabor GE, Gislason T, Jogi R, Juvekar SK, Knox-Brown B, Koul P, Mortimer K, Nafees AA, Nielsen R, Mahesh PA, Paraguas SNM, Rotevatn AØ, Sooronbaev T, Burney PGJ, Amaral AFS; BOLD Collaborative Research Group. Janson C, et al. BMJ Open Respir Res. 2025 Jan 19;12(1):e002442. doi: 10.1136/bmjresp-2024-002442. BMJ Open Respir Res. 2025. PMID: 39832891 Free PMC article.
Rethinking the Pace of Productivity in Pharmacy Academia.
Smith KJ, Cain J, Childs-Kean LM. Smith KJ, et al. Among authors: cain j. Am J Pharm Educ. 2025 Jan;89(1):101338. doi: 10.1016/j.ajpe.2024.101338. Epub 2024 Dec 9. Am J Pharm Educ. 2025. PMID: 39653172
A STAT3-STING-IFN axis controls the metastatic spread of small cell lung cancer.
Guanizo AC, Luong Q, Jayasekara WSN, de Geus ED, Inampudi C, Xue VS, Chen J, de Weerd NA, Matthews AY, Gantier MP, Balic JJ, Arulananda S, Garama DJ, Hertzog PJ, Ganju V, Watkins DN, Cain JE, Gough DJ. Guanizo AC, et al. Among authors: cain je. Nat Immunol. 2024 Dec;25(12):2259-2269. doi: 10.1038/s41590-024-02014-5. Epub 2024 Nov 21. Nat Immunol. 2024. PMID: 39572642
896 results