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Rarity of human T helper 17 cells is due to retinoic acid orphan receptor-dependent mechanisms that limit their expansion.
Santarlasci V, Maggi L, Capone M, Querci V, Beltrame L, Cavalieri D, D'Aiuto E, Cimaz R, Nebbioso A, Liotta F, De Palma R, Maggi E, Cosmi L, Romagnani S, Annunziato F. Santarlasci V, et al. Among authors: querci v. Immunity. 2012 Feb 24;36(2):201-14. doi: 10.1016/j.immuni.2011.12.013. Epub 2012 Feb 9. Immunity. 2012. PMID: 22326581 Free article.
Human interleukin 17-producing cells originate from a CD161+CD4+ T cell precursor.
Cosmi L, De Palma R, Santarlasci V, Maggi L, Capone M, Frosali F, Rodolico G, Querci V, Abbate G, Angeli R, Berrino L, Fambrini M, Caproni M, Tonelli F, Lazzeri E, Parronchi P, Liotta F, Maggi E, Romagnani S, Annunziato F. Cosmi L, et al. Among authors: querci v. J Exp Med. 2008 Aug 4;205(8):1903-16. doi: 10.1084/jem.20080397. Epub 2008 Jul 28. J Exp Med. 2008. PMID: 18663128 Free PMC article.
CD161 is a marker of all human IL-17-producing T-cell subsets and is induced by RORC.
Maggi L, Santarlasci V, Capone M, Peired A, Frosali F, Crome SQ, Querci V, Fambrini M, Liotta F, Levings MK, Maggi E, Cosmi L, Romagnani S, Annunziato F. Maggi L, et al. Among authors: querci v. Eur J Immunol. 2010 Aug;40(8):2174-81. doi: 10.1002/eji.200940257. Eur J Immunol. 2010. PMID: 20486123 Free article.
Distinctive features of classic and nonclassic (Th17 derived) human Th1 cells.
Maggi L, Santarlasci V, Capone M, Rossi MC, Querci V, Mazzoni A, Cimaz R, De Palma R, Liotta F, Maggi E, Romagnani S, Cosmi L, Annunziato F. Maggi L, et al. Among authors: querci v. Eur J Immunol. 2012 Dec;42(12):3180-8. doi: 10.1002/eji.201242648. Epub 2012 Oct 25. Eur J Immunol. 2012. PMID: 22965818 Free article. Clinical Trial.
IL-4-induced gene 1 maintains high Tob1 expression that contributes to TCR unresponsiveness in human T helper 17 cells.
Santarlasci V, Maggi L, Mazzoni A, Capone M, Querci V, Rossi MC, Beltrame L, Cavalieri D, De Palma R, Liotta F, Cosmi L, Maggi E, Romagnani S, Annunziato F. Santarlasci V, et al. Among authors: querci v. Eur J Immunol. 2014 Mar;44(3):654-61. doi: 10.1002/eji.201344047. Epub 2013 Dec 27. Eur J Immunol. 2014. PMID: 24307243 Free article.
Demethylation of the RORC2 and IL17A in human CD4+ T lymphocytes defines Th17 origin of nonclassic Th1 cells.
Mazzoni A, Santarlasci V, Maggi L, Capone M, Rossi MC, Querci V, De Palma R, Chang HD, Thiel A, Cimaz R, Liotta F, Cosmi L, Maggi E, Radbruch A, Romagnani S, Dong J, Annunziato F. Mazzoni A, et al. Among authors: querci v. J Immunol. 2015 Apr 1;194(7):3116-26. doi: 10.4049/jimmunol.1401303. Epub 2015 Mar 4. J Immunol. 2015. PMID: 25740946 Free article.
Brief report: etanercept inhibits the tumor necrosis factor α-driven shift of Th17 lymphocytes toward a nonclassic Th1 phenotype in juvenile idiopathic arthritis.
Maggi L, Cimaz R, Capone M, Santarlasci V, Querci V, Simonini G, Nencini F, Liotta F, Romagnani S, Maggi E, Annunziato F, Cosmi L. Maggi L, et al. Among authors: querci v. Arthritis Rheumatol. 2014 May;66(5):1372-7. doi: 10.1002/art.38355. Arthritis Rheumatol. 2014. PMID: 24470328 Free article.
Human immature myeloid dendritic cells trigger a TH2-polarizing program via Jagged-1/Notch interaction.
Liotta F, Frosali F, Querci V, Mantei A, Filì L, Maggi L, Mazzinghi B, Angeli R, Ronconi E, Santarlasci V, Biagioli T, Lasagni L, Ballerini C, Parronchi P, Scheffold A, Cosmi L, Maggi E, Romagnani S, Annunziato F. Liotta F, et al. Among authors: querci v. J Allergy Clin Immunol. 2008 Apr;121(4):1000-5.e8. doi: 10.1016/j.jaci.2008.01.004. Epub 2008 Mar 4. J Allergy Clin Immunol. 2008. PMID: 18313135
37 results