Hagan CL - Search Results

1

Activation of the Escherichia coli β-barrel assembly machine (Bam) is required for essential components to interact properly with substrate.

Ricci DP, Hagan CL, Kahne D, Silhavy TJ. Ricci DP, et al. Among authors: hagan cl. Proc Natl Acad Sci U S A. 2012 Feb 28;109(9):3487-91. doi: 10.1073/pnas.1201362109. Epub 2012 Feb 13. Proc Natl Acad Sci U S A. 2012. PMID: 22331884 Free PMC article.

2

Reconstitution of outer membrane protein assembly from purified components.

Hagan CL, Kim S, Kahne D. Hagan CL, et al. Science. 2010 May 14;328(5980):890-2. doi: 10.1126/science.1188919. Epub 2010 Apr 8. Science. 2010. PMID: 20378773 Free PMC article.

3

β-Barrel membrane protein assembly by the Bam complex.

Hagan CL, Silhavy TJ, Kahne D. Hagan CL, et al. Annu Rev Biochem. 2011;80:189-210. doi: 10.1146/annurev-biochem-061408-144611. Annu Rev Biochem. 2011. PMID: 21370981 Review.

4

The reconstituted Escherichia coli Bam complex catalyzes multiple rounds of β-barrel assembly.

Hagan CL, Kahne D. Hagan CL, et al. Biochemistry. 2011 Sep 6;50(35):7444-6. doi: 10.1021/bi2010784. Epub 2011 Aug 11. Biochemistry. 2011. PMID: 21823654 Free PMC article.

5

bam Lipoproteins Assemble BamA in vitro.

Hagan CL, Westwood DB, Kahne D. Hagan CL, et al. Biochemistry. 2013 Sep 3;52(35):6108-13. doi: 10.1021/bi400865z. Epub 2013 Aug 21. Biochemistry. 2013. PMID: 23919461 Free PMC article.

6

Inhibition of the β-barrel assembly machine by a peptide that binds BamD.

Hagan CL, Wzorek JS, Kahne D. Hagan CL, et al. Proc Natl Acad Sci U S A. 2015 Feb 17;112(7):2011-6. doi: 10.1073/pnas.1415955112. Epub 2015 Feb 2. Proc Natl Acad Sci U S A. 2015. PMID: 25646443 Free PMC article.

7

Membrane integration of an essential β-barrel protein prerequires burial of an extracellular loop.

Wzorek JS, Lee J, Tomasek D, Hagan CL, Kahne DE. Wzorek JS, et al. Among authors: hagan cl. Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):2598-2603. doi: 10.1073/pnas.1616576114. Epub 2017 Feb 21. Proc Natl Acad Sci U S A. 2017. PMID: 28223520 Free PMC article.

8

Substrate binding to BamD triggers a conformational change in BamA to control membrane insertion.

Lee J, Sutterlin HA, Wzorek JS, Mandler MD, Hagan CL, Grabowicz M, Tomasek D, May MD, Hart EM, Silhavy TJ, Kahne D. Lee J, et al. Among authors: hagan cl. Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):2359-2364. doi: 10.1073/pnas.1711727115. Epub 2018 Feb 20. Proc Natl Acad Sci U S A. 2018. PMID: 29463713 Free PMC article.

9

Site-Specific Photocrosslinking to Investigate Toxin Delivery Mediated by the Bacterial β-Barrel Assembly Machine.

Bouzan EM, Hagan CL. Bouzan EM, et al. Among authors: hagan cl. Methods Mol Biol. 2024;2778:117-131. doi: 10.1007/978-1-0716-3734-0_8. Methods Mol Biol. 2024. PMID: 38478275

10

Bacterial Contact-Dependent Inhibition Protein Binds near the Open Lateral Gate in BamA Prior to Toxin Translocation.

Curley CL, Fedrigoni TP, Flaherty EM, Woodilla CJ, Hagan CL. Curley CL, et al. Among authors: hagan cl. Biochemistry. 2021 Oct 5;60(39):2956-2965. doi: 10.1021/acs.biochem.1c00337. Epub 2021 Sep 20. Biochemistry. 2021. PMID: 34541845

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