Rzuczek SG - Search Results

1

Rationally designed small molecules targeting the RNA that causes myotonic dystrophy type 1 are potently bioactive.

Childs-Disney JL, Hoskins J, Rzuczek SG, Thornton CA, Disney MD. Childs-Disney JL, et al. Among authors: rzuczek sg. ACS Chem Biol. 2012 May 18;7(5):856-62. doi: 10.1021/cb200408a. Epub 2012 Mar 5. ACS Chem Biol. 2012. PMID: 22332923 Free PMC article.

2

Targeting the r(CGG) repeats that cause FXTAS with modularly assembled small molecules and oligonucleotides.

Tran T, Childs-Disney JL, Liu B, Guan L, Rzuczek S, Disney MD. Tran T, et al. ACS Chem Biol. 2014 Apr 18;9(4):904-12. doi: 10.1021/cb400875u. Epub 2014 Feb 19. ACS Chem Biol. 2014. PMID: 24506227 Free PMC article.

3

The Hairpin Form of r(G₄C₂)^exp in c9ALS/FTD Is Repeat-Associated Non-ATG Translated and a Target for Bioactive Small Molecules.

Wang ZF, Ursu A, Childs-Disney JL, Guertler R, Yang WY, Bernat V, Rzuczek SG, Fuerst R, Zhang YJ, Gendron TF, Yildirim I, Dwyer BG, Rice JE, Petrucelli L, Disney MD. Wang ZF, et al. Among authors: rzuczek sg. Cell Chem Biol. 2019 Feb 21;26(2):179-190.e12. doi: 10.1016/j.chembiol.2018.10.018. Epub 2018 Nov 29. Cell Chem Biol. 2019. PMID: 30503283 Free PMC article.

4

A Small Molecule that Binds an RNA Repeat Expansion Stimulates Its Decay via the Exosome Complex.

Angelbello AJ, Benhamou RI, Rzuczek SG, Choudhary S, Tang Z, Chen JL, Roy M, Wang KW, Yildirim I, Jun AS, Thornton CA, Disney MD. Angelbello AJ, et al. Among authors: rzuczek sg. Cell Chem Biol. 2021 Jan 21;28(1):34-45.e6. doi: 10.1016/j.chembiol.2020.10.007. Epub 2020 Nov 5. Cell Chem Biol. 2021. PMID: 33157036 Free PMC article.

5

Features of modularly assembled compounds that impart bioactivity against an RNA target.

Rzuczek SG, Gao Y, Tang ZZ, Thornton CA, Kodadek T, Disney MD. Rzuczek SG, et al. ACS Chem Biol. 2013 Oct 18;8(10):2312-21. doi: 10.1021/cb400265y. Epub 2013 Sep 13. ACS Chem Biol. 2013. PMID: 24032410 Free PMC article.

6

A toxic RNA catalyzes the in cellulo synthesis of its own inhibitor.

Rzuczek SG, Park H, Disney MD. Rzuczek SG, et al. Angew Chem Int Ed Engl. 2014 Oct 6;53(41):10956-9. doi: 10.1002/anie.201406465. Epub 2014 Aug 27. Angew Chem Int Ed Engl. 2014. PMID: 25164984

7

Studying a Drug-like, RNA-Focused Small Molecule Library Identifies Compounds That Inhibit RNA Toxicity in Myotonic Dystrophy.

Rzuczek SG, Southern MR, Disney MD. Rzuczek SG, et al. ACS Chem Biol. 2015 Dec 18;10(12):2706-15. doi: 10.1021/acschembio.5b00430. Epub 2015 Sep 28. ACS Chem Biol. 2015. PMID: 26414664 Free PMC article.

8

Comparison of small molecules and oligonucleotides that target a toxic, non-coding RNA.

Costales MG, Rzuczek SG, Disney MD. Costales MG, et al. Among authors: rzuczek sg. Bioorg Med Chem Lett. 2016 Jun 1;26(11):2605-9. doi: 10.1016/j.bmcl.2016.04.025. Epub 2016 Apr 11. Bioorg Med Chem Lett. 2016. PMID: 27117425

9

Development of pharmacophore models for small molecules targeting RNA: Application to the RNA repeat expansion in myotonic dystrophy type 1.

Angelbello AJ, González ÀL, Rzuczek SG, Disney MD. Angelbello AJ, et al. Among authors: rzuczek sg. Bioorg Med Chem Lett. 2016 Dec 1;26(23):5792-5796. doi: 10.1016/j.bmcl.2016.10.037. Epub 2016 Oct 13. Bioorg Med Chem Lett. 2016. PMID: 27839685 Free PMC article.

10

Precise small-molecule recognition of a toxic CUG RNA repeat expansion.

Rzuczek SG, Colgan LA, Nakai Y, Cameron MD, Furling D, Yasuda R, Disney MD. Rzuczek SG, et al. Nat Chem Biol. 2017 Feb;13(2):188-193. doi: 10.1038/nchembio.2251. Epub 2016 Dec 12. Nat Chem Biol. 2017. PMID: 27941760 Free PMC article.

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My Custom Filters

Publication date

Text availability

Article attribute

Article type

Article Language

Species

Sex

Age

Other

20 results

Search Page

Filters