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Discovery of a novel, first-in-class, orally bioavailable azaindole inhibitor (VX-787) of influenza PB2.
Clark MP, Ledeboer MW, Davies I, Byrn RA, Jones SM, Perola E, Tsai A, Jacobs M, Nti-Addae K, Bandarage UK, Boyd MJ, Bethiel RS, Court JJ, Deng H, Duffy JP, Dorsch WA, Farmer LJ, Gao H, Gu W, Jackson K, Jacobs DH, Kennedy JM, Ledford B, Liang J, Maltais F, Murcko M, Wang T, Wannamaker MW, Bennett HB, Leeman JR, McNeil C, Taylor WP, Memmott C, Jiang M, Rijnbrand R, Bral C, Germann U, Nezami A, Zhang Y, Salituro FG, Bennani YL, Charifson PS. Clark MP, et al. J Med Chem. 2014 Aug 14;57(15):6668-78. doi: 10.1021/jm5007275. Epub 2014 Jul 24. J Med Chem. 2014. PMID: 25019388
Discovery of VX-509 (Decernotinib): A Potent and Selective Janus Kinase 3 Inhibitor for the Treatment of Autoimmune Diseases.
Farmer LJ, Ledeboer MW, Hoock T, Arnost MJ, Bethiel RS, Bennani YL, Black JJ, Brummel CL, Chakilam A, Dorsch WA, Fan B, Cochran JE, Halas S, Harrington EM, Hogan JK, Howe D, Huang H, Jacobs DH, Laitinen LM, Liao S, Mahajan S, Marone V, Martinez-Botella G, McCarthy P, Messersmith D, Namchuk M, Oh L, Penney MS, Pierce AC, Raybuck SA, Rugg A, Salituro FG, Saxena K, Shannon D, Shlyakter D, Swenson L, Tian SK, Town C, Wang J, Wang T, Wannamaker MW, Winquist RJ, Zuccola HJ. Farmer LJ, et al. Among authors: jacobs dh. J Med Chem. 2015 Sep 24;58(18):7195-216. doi: 10.1021/acs.jmedchem.5b00301. Epub 2015 Sep 10. J Med Chem. 2015. PMID: 26230873
Engaging older adults in the process of aging research: a multimethod study evaluating the experience and efficacy of a citizen advisory group for a dementia risk reduction program.
D'Amico D, Savundranayagam MY, Biles R, Itzhak I, Anderson ND; Canadian Consortium on Neurodegeneration in Aging (CCNA) CAN-THUMBS UP Study Group. D'Amico D, et al. Res Involv Engagem. 2024 Dec 27;10(1):135. doi: 10.1186/s40900-024-00643-6. Res Involv Engagem. 2024. PMID: 39731188 Free PMC article.
Changing Medicare Payment to Strengthen Primary Care.
Jacobs DB, LaBonte CT, Seshamani M. Jacobs DB, et al. N Engl J Med. 2024 Dec 18. doi: 10.1056/NEJMp2413193. Online ahead of print. N Engl J Med. 2024. PMID: 39693561 No abstract available.
Inflammation biomarkers and neurobehavioral performance in rural adolescents.
Amdemicael B, Yang K, Chronister BNC, Mackey C, Tu X, Gahagan S, Martinez D, Checkoway H, Jacobs DR Jr, Suarez-Torres J, Hong S, Suarez-Lopez JR. Amdemicael B, et al. Among authors: jacobs dr jr. Brain Behav Immun Health. 2024 Nov 23;43:100912. doi: 10.1016/j.bbih.2024.100912. eCollection 2025 Feb. Brain Behav Immun Health. 2024. PMID: 39686922 Free PMC article.
3,136 results