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Phase I Study of [68Ga]Ga-Anti-CD206-sdAb for PET/CT Assessment of Protumorigenic Macrophage Presence in Solid Tumors (MMR Phase I).
Gondry O, Xavier C, Raes L, Heemskerk J, Devoogdt N, Everaert H, Breckpot K, Lecocq Q, Decoster L, Fontaine C, Schallier D, Aspeslagh S, Vaneycken I, Raes G, Van Ginderachter JA, Lahoutte T, Caveliers V, Keyaerts M. Gondry O, et al. Among authors: van ginderachter ja. J Nucl Med. 2023 Sep;64(9):1378-1384. doi: 10.2967/jnumed.122.264853. Epub 2023 Jul 20. J Nucl Med. 2023. PMID: 37474271 Free PMC article. Clinical Trial.
Current status and future expectations of nanobodies in oncology trials.
De Pauw T, De Mey L, Debacker JM, Raes G, Van Ginderachter JA, De Groof TWM, Devoogdt N. De Pauw T, et al. Among authors: van ginderachter ja. Expert Opin Investig Drugs. 2023 Jul-Dec;32(8):705-721. doi: 10.1080/13543784.2023.2249814. Epub 2023 Aug 28. Expert Opin Investig Drugs. 2023. PMID: 37638538 Free article. Review.
Whole-mouse clearing and imaging at the cellular level with vDISCO.
Cai R, Kolabas ZI, Pan C, Mai H, Zhao S, Kaltenecker D, Voigt FF, Molbay M, Ohn TL, Vincke C, Todorov MI, Helmchen F, Van Ginderachter JA, Ertürk A. Cai R, et al. Among authors: van ginderachter ja. Nat Protoc. 2023 Apr;18(4):1197-1242. doi: 10.1038/s41596-022-00788-2. Epub 2023 Jan 25. Nat Protoc. 2023. PMID: 36697871 Review.
Specific imaging of CD8 + T-Cell dynamics with a nanobody radiotracer against human CD8β.
De Groof TWM, Lauwers Y, De Pauw T, Saxena M, Vincke C, Van Craenenbroeck J, Chapon C, Le Grand R, Raes G, Naninck T, Van Ginderachter JA, Devoogdt N. De Groof TWM, et al. Among authors: van ginderachter ja. Eur J Nucl Med Mol Imaging. 2024 Dec;52(1):193-207. doi: 10.1007/s00259-024-06896-3. Epub 2024 Sep 2. Eur J Nucl Med Mol Imaging. 2024. PMID: 39218831 Free PMC article.
Size-advantage of monovalent nanobodies against the macrophage mannose receptor for deep tumor penetration and tumor-associated macrophage targeting.
Erreni M, D'Autilia F, Avigni R, Bolli E, Arnouk SM, Movahedi K, Debie P, Anselmo A, Parente R, Vincke C, van Leeuwen FWB, Allavena P, Garlanda C, Mantovani A, Doni A, Hernot S, Van Ginderachter JA. Erreni M, et al. Among authors: van leeuwen fwb, van ginderachter ja. Theranostics. 2023 Jan 1;13(1):355-373. doi: 10.7150/thno.77560. eCollection 2023. Theranostics. 2023. PMID: 36593955 Free PMC article.
A few good reasons to use nanobodies for cancer treatment.
Jumapili NA, Zivalj M, Barthelmess RM, Raes G, De Groof TWM, Devoogdt N, Stijlemans B, Vincke C, Van Ginderachter JA. Jumapili NA, et al. Among authors: van ginderachter ja. Eur J Immunol. 2023 Sep;53(9):e2250024. doi: 10.1002/eji.202250024. Epub 2023 Jun 27. Eur J Immunol. 2023. PMID: 37366246 Free article. Review.
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