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Determination of the GABA(B) receptor agonist CGP 44532 (3-amino-2-hydroxypropylmethylphosphinic acid) in rat plasma after pre-column derivatization by micro-high-performance liquid chromatography combined with negative electrospray tandem mass spectrometry.
Blum W, Aichholz R, Ramstein P, Kühnöl J, Froestl W, Desrayaud S. Blum W, et al. Among authors: aichholz r. J Chromatogr B Biomed Sci Appl. 2000 Oct 10;748(2):349-59. doi: 10.1016/s0378-4347(00)00352-2. J Chromatogr B Biomed Sci Appl. 2000. PMID: 11087077
In vivo metabolism of epothilone B in tumor-bearing nude mice: identification of three new epothilone B metabolites by capillary high-pressure liquid chromatography/mass spectrometry/tandem mass spectrometry.
Blum W, Aichholz R, Ramstein P, Kühnöl J, Brüggen J, O'Reilly T, Flörsheimer A. Blum W, et al. Among authors: aichholz r. Rapid Commun Mass Spectrom. 2001;15(1):41-9. doi: 10.1002/1097-0231(20010115)15:1<41::AID-RCM190>3.0.CO;2-W. Rapid Commun Mass Spectrom. 2001. PMID: 11135423
Complementary use of ion trap/time-of-flight mass spectrometry in combination with capillary high-pressure liquid chromatography: early characterization of in vivo metabolites of the cathepsin K inhibitor NVP-AAV490 in rat.
Blum W, Buhl T, Altmann E, Kühnöl J, Ramstein P, Aichholz R. Blum W, et al. Among authors: aichholz r. J Chromatogr B Analyt Technol Biomed Life Sci. 2003 Apr 25;787(2):255-70. doi: 10.1016/s1570-0232(02)00782-1. J Chromatogr B Analyt Technol Biomed Life Sci. 2003. PMID: 12650749
Micropreparative isolation and NMR structure elucidation of metabolites of the drug candidate 1-isopropyl-4-(4-isopropylphenyl)-6-(prop-2-yn-1-yloxy) quinazolin-2(1H)-one from rat bile and urine.
Blanz J, Délémonté T, Pearson D, Luneau A, Ritzau M, Gertsch W, Ramstein P, Dayer J, Desrayaud S, Braun E, Aichholz R. Blanz J, et al. Among authors: aichholz r. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 May 1;989:1-10. doi: 10.1016/j.jchromb.2015.02.044. Epub 2015 Mar 10. J Chromatogr B Analyt Technol Biomed Life Sci. 2015. PMID: 25797717
Increasing metabolic stability via the deuterium kinetic isotope effect: An example from a proline-amide-urea aminothiazole series of phosphatidylinositol-3 kinase alpha inhibitors.
Fairhurst RA, Caravatti G, Guagnano V, Aichholz R, Blanz J, Blasco F, Wipfli P, Fritsch C, Maira SM, Schnell C, Seiler FH. Fairhurst RA, et al. Among authors: aichholz r. Bioorg Med Chem Lett. 2016 Oct 1;26(19):4729-4734. doi: 10.1016/j.bmcl.2016.08.041. Epub 2016 Aug 17. Bioorg Med Chem Lett. 2016. PMID: 27575470
Discovery and profiling of a selective and efficacious Syk inhibitor.
Thoma G, Smith AB, van Eis MJ, Vangrevelinghe E, Blanz J, Aichholz R, Littlewood-Evans A, Lee CC, Liu H, Zerwes HG. Thoma G, et al. Among authors: aichholz r. J Med Chem. 2015 Feb 26;58(4):1950-63. doi: 10.1021/jm5018863. Epub 2015 Feb 9. J Med Chem. 2015. PMID: 25633741
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