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Lysine 624 of the amyloid precursor protein (APP) is a critical determinant of amyloid β peptide length: support for a sequential model of γ-secretase intramembrane proteolysis and regulation by the amyloid β precursor protein (APP) juxtamembrane region.
Kukar TL, Ladd TB, Robertson P, Pintchovski SA, Moore B, Bann MA, Ren Z, Jansen-West K, Malphrus K, Eggert S, Maruyama H, Cottrell BA, Das P, Basi GS, Koo EH, Golde TE. Kukar TL, et al. Among authors: eggert s. J Biol Chem. 2011 Nov 18;286(46):39804-12. doi: 10.1074/jbc.M111.274696. Epub 2011 Aug 25. J Biol Chem. 2011. PMID: 21868378 Free PMC article.
Amyloid precursor protein (APP) regulates synaptic structure and function.
Tyan SH, Shih AY, Walsh JJ, Maruyama H, Sarsoza F, Ku L, Eggert S, Hof PR, Koo EH, Dickstein DL. Tyan SH, et al. Among authors: eggert s. Mol Cell Neurosci. 2012 Aug;51(1-2):43-52. doi: 10.1016/j.mcn.2012.07.009. Epub 2012 Aug 3. Mol Cell Neurosci. 2012. PMID: 22884903 Free PMC article.
Differential effects of familial Alzheimer's disease-causing mutations on amyloid precursor protein (APP) trafficking, proteolytic conversion, and synaptogenic activity.
Schilling S, Pradhan A, Heesch A, Helbig A, Blennow K, Koch C, Bertgen L, Koo EH, Brinkmalm G, Zetterberg H, Kins S, Eggert S. Schilling S, et al. Among authors: eggert s. Acta Neuropathol Commun. 2023 Jun 1;11(1):87. doi: 10.1186/s40478-023-01577-y. Acta Neuropathol Commun. 2023. PMID: 37259128 Free PMC article.
156 results