Freund SM - Search Results

1

An intrinsically labile α-helix abutting the BCL9-binding site of β-catenin is required for its inhibition by carnosic acid.

de la Roche M, Rutherford TJ, Gupta D, Veprintsev DB, Saxty B, Freund SM, Bienz M. de la Roche M, et al. Among authors: freund sm. Nat Commun. 2012 Feb 21;3:680. doi: 10.1038/ncomms1680. Nat Commun. 2012. PMID: 22353711 Free PMC article.

2

A peptide that binds and stabilizes p53 core domain: chaperone strategy for rescue of oncogenic mutants.

Friedler A, Hansson LO, Veprintsev DB, Freund SM, Rippin TM, Nikolova PV, Proctor MR, Rüdiger S, Fersht AR. Friedler A, et al. Among authors: freund sm. Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):937-42. doi: 10.1073/pnas.241629998. Epub 2002 Jan 8. Proc Natl Acad Sci U S A. 2002. PMID: 11782540 Free PMC article.

3

Recognition of DNA by p53 core domain and location of intermolecular contacts of cooperative binding.

Rippin TM, Freund SM, Veprintsev DB, Fersht AR. Rippin TM, et al. Among authors: freund sm. J Mol Biol. 2002 May 31;319(2):351-8. doi: 10.1016/S0022-2836(02)00326-1. J Mol Biol. 2002. PMID: 12051912

4

CRINEPT-TROSY NMR reveals p53 core domain bound in an unfolded form to the chaperone Hsp90.

Rudiger S, Freund SM, Veprintsev DB, Fersht AR. Rudiger S, et al. Among authors: freund sm. Proc Natl Acad Sci U S A. 2002 Aug 20;99(17):11085-90. doi: 10.1073/pnas.132393699. Epub 2002 Aug 5. Proc Natl Acad Sci U S A. 2002. PMID: 12163643 Free PMC article.

5

Hydrophobic core fluidity of homologous protein domains: relation of side-chain dynamics to core composition and packing.

Best RB, Rutherford TJ, Freund SM, Clarke J. Best RB, et al. Among authors: freund sm. Biochemistry. 2004 Feb 10;43(5):1145-55. doi: 10.1021/bi035658e. Biochemistry. 2004. PMID: 14756550

6

Regulation of DNA binding of p53 by its C-terminal domain.

Weinberg RL, Freund SM, Veprintsev DB, Bycroft M, Fersht AR. Weinberg RL, et al. Among authors: freund sm. J Mol Biol. 2004 Sep 17;342(3):801-11. doi: 10.1016/j.jmb.2004.07.042. J Mol Biol. 2004. PMID: 15342238

7

Modulation of binding of DNA to the C-terminal domain of p53 by acetylation.

Friedler A, Veprintsev DB, Freund SM, von Glos KI, Fersht AR. Friedler A, et al. Among authors: freund sm. Structure. 2005 Apr;13(4):629-36. doi: 10.1016/j.str.2005.01.020. Structure. 2005. PMID: 15837201 Free article.

8

Binding of EMSY to HP1beta: implications for recruitment of HP1beta and BS69.

Ekblad CM, Chavali GB, Basu BP, Freund SM, Veprintsev D, Hughes-Davies L, Kouzarides T, Doherty AJ, Itzhaki LS. Ekblad CM, et al. Among authors: freund sm. EMBO Rep. 2005 Jul;6(7):675-80. doi: 10.1038/sj.embor.7400415. EMBO Rep. 2005. PMID: 15947784 Free PMC article.

9

Solution structure of a protein denatured state and folding intermediate.

Religa TL, Markson JS, Mayor U, Freund SM, Fersht AR. Religa TL, et al. Among authors: freund sm. Nature. 2005 Oct 13;437(7061):1053-6. doi: 10.1038/nature04054. Nature. 2005. PMID: 16222301

10

The central region of HDM2 provides a second binding site for p53.

Yu GW, Rudiger S, Veprintsev D, Freund S, Fernandez-Fernandez MR, Fersht AR. Yu GW, et al. Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1227-32. doi: 10.1073/pnas.0510343103. Epub 2006 Jan 23. Proc Natl Acad Sci U S A. 2006. PMID: 16432196 Free PMC article.

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