Loche A - Search Results

1

GET73 modulates rat hippocampal glutamate transmission: evidence for a functional interaction with mGluR5.

Ferraro L, Beggiato S, Tomasini MC, Antonelli T, Loche A, Tanganelli S. Ferraro L, et al. Among authors: loche a. Pharmacol Rep. 2011;63(6):1359-71. doi: 10.1016/s1734-1140(11)70700-9. Pharmacol Rep. 2011. PMID: 22358084 Free article.

2

gamma-Hydroxybutyrate modulation of glutamate levels in the hippocampus: an in vivo and in vitro study.

Ferraro L, Tanganelli S, O'Connor WT, Francesconi W, Loche A, Gessa GL, Antonelli T. Ferraro L, et al. Among authors: loche a. J Neurochem. 2001 Sep;78(5):929-39. doi: 10.1046/j.1471-4159.2001.00530.x. J Neurochem. 2001. PMID: 11553667 Free article.

3

Preference for palatable food is reduced by the gamma-hydroxybutyrate analogue GET73, in rats.

Ottani A, Leone S, Vergara FB, Tacchi R, Loche A, Bertolini A. Ottani A, et al. Among authors: loche a. Pharmacol Res. 2007 Apr;55(4):271-9. doi: 10.1016/j.phrs.2006.12.002. Epub 2006 Dec 19. Pharmacol Res. 2007. PMID: 17240159

4

Sucrose intake: increase in non-stressed rats and reduction in chronically stressed rats are both prevented by the gamma-hydroxybutyrate (GHB) analogue, GET73.

Tacchi R, Ferrari A, Loche A, Bertolini A. Tacchi R, et al. Among authors: loche a. Pharmacol Res. 2008 Jun;57(6):464-8. doi: 10.1016/j.phrs.2008.05.004. Epub 2008 May 21. Pharmacol Res. 2008. PMID: 18573666

5

GET73 increases rat extracellular hippocampal CA1 GABA levels through a possible involvement of local mGlu5 receptor.

Beggiato S, O'Connor WT, Tomasini MC, Antonelli T, Loche A, Tanganelli S, Cacciaglia R, Ferraro L. Beggiato S, et al. Among authors: loche a. Synapse. 2013 Oct;67(10):678-91. doi: 10.1002/syn.21672. Epub 2013 May 21. Synapse. 2013. PMID: 23564259

6

The new compound GET73, N-[(4-trifluoromethyl)benzyl]4-methoxybutyramide, Regulates hippocampal Aminoacidergic transmission possibly via an allosteric modulation of mGlu5 receptor. Behavioural evidence of its "anti-alcohol" and anxiolytic properties.

Ferraro L, Loche A, Beggiato S, Tomasini MC, Antonelli T, Colombo G, Lobina C, Carai MA, Porcu A, Castelli MP, Clerici F, Borelli AC, Cacciaglia R, Tanganelli S. Ferraro L, et al. Among authors: loche a. Curr Med Chem. 2013;20(27):3339-57. doi: 10.2174/09298673113209990167. Curr Med Chem. 2013. PMID: 23862615 Review.

7

GET73 Prevents Ethanol-Induced Neurotoxicity in Primary Cultures of Rat Hippocampal Neurons.

Tomasini MC, Borelli AC, Beggiato S, Tanganelli S, Loche A, Cacciaglia R, Ferraro L, Antonelli T. Tomasini MC, et al. Among authors: loche a. Alcohol Alcohol. 2016 Mar;51(2):128-35. doi: 10.1093/alcalc/agv094. Epub 2015 Aug 12. Alcohol Alcohol. 2016. PMID: 26271115

8

In Vitro Functional Characterization of GET73 as Possible Negative Allosteric Modulator of Metabotropic Glutamate Receptor 5.

Beggiato S, Borelli AC, Tomasini MC, Castelli MP, Pintori N, Cacciaglia R, Loche A, Ferraro L. Beggiato S, et al. Among authors: loche a. Front Pharmacol. 2018 Apr 5;9:327. doi: 10.3389/fphar.2018.00327. eCollection 2018. Front Pharmacol. 2018. PMID: 29674969 Free PMC article.

9

GET73 modulates lipopolysaccharide- and ethanol-induced increase in cytokine/chemokine levels in primary cultures of microglia of rat cerebral cortex.

Tomasini MC, Loche A, Cacciaglia R, Ferraro L, Beggiato S. Tomasini MC, et al. Among authors: loche a. Pharmacol Rep. 2024 Oct;76(5):1174-1183. doi: 10.1007/s43440-024-00632-2. Epub 2024 Aug 1. Pharmacol Rep. 2024. PMID: 39088104

10

Gamma-hydroxybutyrate reduces GABA(A)-mediated inhibitory postsynaptic potentials in the CA1 region of hippocampus.

Cammalleri M, Brancucci A, Berton F, Loche A, Gessa GL, Francesconi W. Cammalleri M, et al. Among authors: loche a. Neuropsychopharmacology. 2002 Dec;27(6):960-9. doi: 10.1016/S0893-133X(02)00378-0. Neuropsychopharmacology. 2002. PMID: 12464453

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