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Cleavage Specificity of Mycobacterium tuberculosis ClpP1P2 Protease and Identification of Novel Peptide Substrates and Boronate Inhibitors with Anti-bacterial Activity.
Akopian T, Kandror O, Tsu C, Lai JH, Wu W, Liu Y, Zhao P, Park A, Wolf L, Dick LR, Rubin EJ, Bachovchin W, Goldberg AL. Akopian T, et al. Among authors: goldberg al. J Biol Chem. 2015 Apr 24;290(17):11008-20. doi: 10.1074/jbc.M114.625640. Epub 2015 Mar 10. J Biol Chem. 2015. PMID: 25759383 Free PMC article.
Bacterial proteolytic complexes as therapeutic targets.
Raju RM, Goldberg AL, Rubin EJ. Raju RM, et al. Among authors: goldberg al. Nat Rev Drug Discov. 2012 Oct;11(10):777-89. doi: 10.1038/nrd3846. Nat Rev Drug Discov. 2012. PMID: 23023677 Review.
The cyclic peptide ecumicin targeting ClpC1 is active against Mycobacterium tuberculosis in vivo.
Gao W, Kim JY, Anderson JR, Akopian T, Hong S, Jin YY, Kandror O, Kim JW, Lee IA, Lee SY, McAlpine JB, Mulugeta S, Sunoqrot S, Wang Y, Yang SH, Yoon TM, Goldberg AL, Pauli GF, Suh JW, Franzblau SG, Cho S. Gao W, et al. Among authors: goldberg al. Antimicrob Agents Chemother. 2015 Feb;59(2):880-9. doi: 10.1128/AAC.04054-14. Epub 2014 Nov 24. Antimicrob Agents Chemother. 2015. PMID: 25421483 Free PMC article.
447 results