Shokat KM - Search Results

1

The translational landscape of mTOR signalling steers cancer initiation and metastasis.

Hsieh AC, Liu Y, Edlind MP, Ingolia NT, Janes MR, Sher A, Shi EY, Stumpf CR, Christensen C, Bonham MJ, Wang S, Ren P, Martin M, Jessen K, Feldman ME, Weissman JS, Shokat KM, Rommel C, Ruggero D. Hsieh AC, et al. Among authors: shokat km. Nature. 2012 Feb 22;485(7396):55-61. doi: 10.1038/nature10912. Nature. 2012. PMID: 22367541 Free PMC article.

2

Mutant tyrosine kinases with unnatural nucleotide specificity retain the structure and phospho-acceptor specificity of the wild-type enzyme.

Witucki LA, Huang X, Shah K, Liu Y, Kyin S, Eck MJ, Shokat KM. Witucki LA, et al. Among authors: shokat km. Chem Biol. 2002 Jan;9(1):25-33. doi: 10.1016/s1074-5521(02)00091-1. Chem Biol. 2002. PMID: 11841936

3

Targets of the cyclin-dependent kinase Cdk1.

Ubersax JA, Woodbury EL, Quang PN, Paraz M, Blethrow JD, Shah K, Shokat KM, Morgan DO. Ubersax JA, et al. Among authors: shokat km. Nature. 2003 Oct 23;425(6960):859-64. doi: 10.1038/nature02062. Nature. 2003. PMID: 14574415

4

A second-site suppressor strategy for chemical genetic analysis of diverse protein kinases.

Zhang C, Kenski DM, Paulson JL, Bonshtien A, Sessa G, Cross JV, Templeton DJ, Shokat KM. Zhang C, et al. Among authors: shokat km. Nat Methods. 2005 Jun;2(6):435-41. doi: 10.1038/nmeth764. Nat Methods. 2005. PMID: 15908922

5

Escape from HER-family tyrosine kinase inhibitor therapy by the kinase-inactive HER3.

Sergina NV, Rausch M, Wang D, Blair J, Hann B, Shokat KM, Moasser MM. Sergina NV, et al. Among authors: shokat km. Nature. 2007 Jan 25;445(7126):437-41. doi: 10.1038/nature05474. Epub 2007 Jan 7. Nature. 2007. PMID: 17206155 Free PMC article.

6

Ablation of PI3K blocks BCR-ABL leukemogenesis in mice, and a dual PI3K/mTOR inhibitor prevents expansion of human BCR-ABL+ leukemia cells.

Kharas MG, Janes MR, Scarfone VM, Lilly MB, Knight ZA, Shokat KM, Fruman DA. Kharas MG, et al. Among authors: shokat km. J Clin Invest. 2008 Sep;118(9):3038-50. doi: 10.1172/JCI33337. J Clin Invest. 2008. PMID: 18704194 Free PMC article.

7

Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases.

Apsel B, Blair JA, Gonzalez B, Nazif TM, Feldman ME, Aizenstein B, Hoffman R, Williams RL, Shokat KM, Knight ZA. Apsel B, et al. Among authors: shokat km. Nat Chem Biol. 2008 Nov;4(11):691-9. doi: 10.1038/nchembio.117. Epub 2008 Oct 12. Nat Chem Biol. 2008. PMID: 18849971 Free PMC article.

8

The unfolded protein response signals through high-order assembly of Ire1.

Korennykh AV, Egea PF, Korostelev AA, Finer-Moore J, Zhang C, Shokat KM, Stroud RM, Walter P. Korennykh AV, et al. Among authors: shokat km. Nature. 2009 Feb 5;457(7230):687-93. doi: 10.1038/nature07661. Epub 2008 Dec 14. Nature. 2009. PMID: 19079236 Free PMC article.

9

EGFR signals to mTOR through PKC and independently of Akt in glioma.

Fan QW, Cheng C, Knight ZA, Haas-Kogan D, Stokoe D, James CD, McCormick F, Shokat KM, Weiss WA. Fan QW, et al. Among authors: shokat km. Sci Signal. 2009 Jan 27;2(55):ra4. doi: 10.1126/scisignal.2000014. Sci Signal. 2009. PMID: 19176518 Free PMC article.

10

Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2.

Feldman ME, Apsel B, Uotila A, Loewith R, Knight ZA, Ruggero D, Shokat KM. Feldman ME, et al. Among authors: shokat km. PLoS Biol. 2009 Feb 10;7(2):e38. doi: 10.1371/journal.pbio.1000038. PLoS Biol. 2009. PMID: 19209957 Free PMC article.

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