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TH-302, a hypoxia-activated prodrug with broad in vivo preclinical combination therapy efficacy: optimization of dosing regimens and schedules.
Liu Q, Sun JD, Wang J, Ahluwalia D, Baker AF, Cranmer LD, Ferraro D, Wang Y, Duan JX, Ammons WS, Curd JG, Matteucci MD, Hart CP. Liu Q, et al. Among authors: baker af. Cancer Chemother Pharmacol. 2012 Jun;69(6):1487-98. doi: 10.1007/s00280-012-1852-8. Epub 2012 Mar 2. Cancer Chemother Pharmacol. 2012. PMID: 22382881 Free PMC article.
Pyruvate sensitizes pancreatic tumors to hypoxia-activated prodrug TH-302.
Wojtkowiak JW, Cornnell HC, Matsumoto S, Saito K, Takakusagi Y, Dutta P, Kim M, Zhang X, Leos R, Bailey KM, Martinez G, Lloyd MC, Weber C, Mitchell JB, Lynch RM, Baker AF, Gatenby RA, Rejniak KA, Hart C, Krishna MC, Gillies RJ. Wojtkowiak JW, et al. Among authors: baker af. Cancer Metab. 2015 Jan 29;3(1):2. doi: 10.1186/s40170-014-0026-z. eCollection 2015. Cancer Metab. 2015. PMID: 25635223 Free PMC article.
A randomized phase II study of PX-12, an inhibitor of thioredoxin in patients with advanced cancer of the pancreas following progression after a gemcitabine-containing combination.
Ramanathan RK, Abbruzzese J, Dragovich T, Kirkpatrick L, Guillen JM, Baker AF, Pestano LA, Green S, Von Hoff DD. Ramanathan RK, et al. Among authors: baker af. Cancer Chemother Pharmacol. 2011 Mar;67(3):503-9. doi: 10.1007/s00280-010-1343-8. Epub 2010 May 12. Cancer Chemother Pharmacol. 2011. PMID: 20461382 Clinical Trial.
Management strategies in pancreatic cancer.
Campen CJ, Dragovich T, Baker AF. Campen CJ, et al. Among authors: baker af. Am J Health Syst Pharm. 2011 Apr 1;68(7):573-84. doi: 10.2146/ajhp100254. Am J Health Syst Pharm. 2011. PMID: 21411798 Review.
52 results