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The IL-6/sIL-6R complex as a novel target for therapeutic approaches.
Rose-John S, Waetzig GH, Scheller J, Grötzinger J, Seegert D. Rose-John S, et al. Among authors: seegert d. Expert Opin Ther Targets. 2007 May;11(5):613-24. doi: 10.1517/14728222.11.5.613. Expert Opin Ther Targets. 2007. PMID: 17465721 Review.
Transgenic blockade of interleukin 6 transsignaling abrogates inflammation.
Rabe B, Chalaris A, May U, Waetzig GH, Seegert D, Williams AS, Jones SA, Rose-John S, Scheller J. Rabe B, et al. Among authors: seegert d. Blood. 2008 Feb 1;111(3):1021-8. doi: 10.1182/blood-2007-07-102137. Epub 2007 Nov 7. Blood. 2008. PMID: 17989316 Free article.
N-linked glycosylation is essential for the stability but not the signaling function of the interleukin-6 signal transducer glycoprotein 130.
Waetzig GH, Chalaris A, Rosenstiel P, Suthaus J, Holland C, Karl N, Vallés Uriarte L, Till A, Scheller J, Grötzinger J, Schreiber S, Rose-John S, Seegert D. Waetzig GH, et al. Among authors: seegert d. J Biol Chem. 2010 Jan 15;285(3):1781-9. doi: 10.1074/jbc.M109.075952. Epub 2009 Nov 13. J Biol Chem. 2010. PMID: 19915009 Free PMC article.
Transsignaling of interleukin-6 crucially contributes to atherosclerosis in mice.
Schuett H, Oestreich R, Waetzig GH, Annema W, Luchtefeld M, Hillmer A, Bavendiek U, von Felden J, Divchev D, Kempf T, Wollert KC, Seegert D, Rose-John S, Tietge UJ, Schieffer B, Grote K. Schuett H, et al. Among authors: seegert d. Arterioscler Thromb Vasc Biol. 2012 Feb;32(2):281-90. doi: 10.1161/ATVBAHA.111.229435. Epub 2011 Nov 10. Arterioscler Thromb Vasc Biol. 2012. PMID: 22075248
A short isoform of NOD2/CARD15, NOD2-S, is an endogenous inhibitor of NOD2/receptor-interacting protein kinase 2-induced signaling pathways.
Rosenstiel P, Huse K, Till A, Hampe J, Hellmig S, Sina C, Billmann S, von Kampen O, Waetzig GH, Platzer M, Seegert D, Schreiber S. Rosenstiel P, et al. Among authors: seegert d. Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3280-5. doi: 10.1073/pnas.0505423103. Epub 2006 Feb 21. Proc Natl Acad Sci U S A. 2006. PMID: 16492792 Free PMC article.
33 results