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Page 1
The IL-6/sIL-6R complex as a novel target for therapeutic approaches.
Rose-John S, Waetzig GH, Scheller J, Grötzinger J, Seegert D. Rose-John S, et al. Among authors: waetzig gh. Expert Opin Ther Targets. 2007 May;11(5):613-24. doi: 10.1517/14728222.11.5.613. Expert Opin Ther Targets. 2007. PMID: 17465721 Review.
Transgenic blockade of interleukin 6 transsignaling abrogates inflammation.
Rabe B, Chalaris A, May U, Waetzig GH, Seegert D, Williams AS, Jones SA, Rose-John S, Scheller J. Rabe B, et al. Among authors: waetzig gh. Blood. 2008 Feb 1;111(3):1021-8. doi: 10.1182/blood-2007-07-102137. Epub 2007 Nov 7. Blood. 2008. PMID: 17989316 Free article.
N-linked glycosylation is essential for the stability but not the signaling function of the interleukin-6 signal transducer glycoprotein 130.
Waetzig GH, Chalaris A, Rosenstiel P, Suthaus J, Holland C, Karl N, Vallés Uriarte L, Till A, Scheller J, Grötzinger J, Schreiber S, Rose-John S, Seegert D. Waetzig GH, et al. J Biol Chem. 2010 Jan 15;285(3):1781-9. doi: 10.1074/jbc.M109.075952. Epub 2009 Nov 13. J Biol Chem. 2010. PMID: 19915009 Free PMC article.
Essential role of neutrophil mobilization in concanavalin A-induced hepatitis is based on classic IL-6 signaling but not on IL-6 trans-signaling.
Malchow S, Thaiss W, Jänner N, Waetzig GH, Gewiese-Rabsch J, Garbers C, Yamamoto K, Rose-John S, Scheller J. Malchow S, et al. Among authors: waetzig gh. Biochim Biophys Acta. 2011 Mar;1812(3):290-301. doi: 10.1016/j.bbadis.2010.11.009. Epub 2010 Dec 2. Biochim Biophys Acta. 2011. PMID: 21130161 Free article.
Inhibition of classic signaling is a novel function of soluble glycoprotein 130 (sgp130), which is controlled by the ratio of interleukin 6 and soluble interleukin 6 receptor.
Garbers C, Thaiss W, Jones GW, Waetzig GH, Lorenzen I, Guilhot F, Lissilaa R, Ferlin WG, Grötzinger J, Jones SA, Rose-John S, Scheller J. Garbers C, et al. Among authors: waetzig gh. J Biol Chem. 2011 Dec 16;286(50):42959-70. doi: 10.1074/jbc.M111.295758. Epub 2011 Oct 11. J Biol Chem. 2011. PMID: 21990364 Free PMC article.
Transsignaling of interleukin-6 crucially contributes to atherosclerosis in mice.
Schuett H, Oestreich R, Waetzig GH, Annema W, Luchtefeld M, Hillmer A, Bavendiek U, von Felden J, Divchev D, Kempf T, Wollert KC, Seegert D, Rose-John S, Tietge UJ, Schieffer B, Grote K. Schuett H, et al. Among authors: waetzig gh. Arterioscler Thromb Vasc Biol. 2012 Feb;32(2):281-90. doi: 10.1161/ATVBAHA.111.229435. Epub 2011 Nov 10. Arterioscler Thromb Vasc Biol. 2012. PMID: 22075248
53 results