Hart CP - Search Results

1

Hypoxia promotes dissemination of multiple myeloma through acquisition of epithelial to mesenchymal transition-like features.

Azab AK, Hu J, Quang P, Azab F, Pitsillides C, Awwad R, Thompson B, Maiso P, Sun JD, Hart CP, Roccaro AM, Sacco A, Ngo HT, Lin CP, Kung AL, Carrasco RD, Vanderkerken K, Ghobrial IM. Azab AK, et al. Among authors: hart cp. Blood. 2012 Jun 14;119(24):5782-94. doi: 10.1182/blood-2011-09-380410. Epub 2012 Mar 6. Blood. 2012. PMID: 22394600 Free PMC article.

2

Targeting the multiple myeloma hypoxic niche with TH-302, a hypoxia-activated prodrug.

Hu J, Handisides DR, Van Valckenborgh E, De Raeve H, Menu E, Vande Broek I, Liu Q, Sun JD, Van Camp B, Hart CP, Vanderkerken K. Hu J, et al. Among authors: hart cp. Blood. 2010 Sep 2;116(9):1524-7. doi: 10.1182/blood-2010-02-269126. Epub 2010 Jun 7. Blood. 2010. PMID: 20530289 Free article.

3

Synergistic induction of apoptosis in multiple myeloma cells by bortezomib and hypoxia-activated prodrug TH-302, in vivo and in vitro.

Hu J, Van Valckenborgh E, Xu D, Menu E, De Raeve H, De Bruyne E, Xu S, Van Camp B, Handisides D, Hart CP, Vanderkerken K. Hu J, et al. Among authors: hart cp. Mol Cancer Ther. 2013 Sep;12(9):1763-73. doi: 10.1158/1535-7163.MCT-13-0123. Epub 2013 Jul 5. Mol Cancer Ther. 2013. PMID: 23832122

4

Hypoxia-Targeting Drug Evofosfamide (TH-302) Enhances Sunitinib Activity in Neuroblastoma Xenograft Models.

Kumar S, Sun JD, Zhang L, Mokhtari RB, Wu B, Meng F, Liu Q, Bhupathi D, Wang Y, Yeger H, Hart C, Baruchel S. Kumar S, et al. Transl Oncol. 2018 Aug;11(4):911-919. doi: 10.1016/j.tranon.2018.05.004. Epub 2018 May 31. Transl Oncol. 2018. PMID: 29803017 Free PMC article.

5

Selective tumor hypoxia targeting by hypoxia-activated prodrug TH-302 inhibits tumor growth in preclinical models of cancer.

Sun JD, Liu Q, Wang J, Ahluwalia D, Ferraro D, Wang Y, Duan JX, Ammons WS, Curd JG, Matteucci MD, Hart CP. Sun JD, et al. Among authors: hart cp. Clin Cancer Res. 2012 Feb 1;18(3):758-70. doi: 10.1158/1078-0432.CCR-11-1980. Epub 2011 Dec 19. Clin Cancer Res. 2012. PMID: 22184053

6

TH-302, a hypoxia-activated prodrug with broad in vivo preclinical combination therapy efficacy: optimization of dosing regimens and schedules.

Liu Q, Sun JD, Wang J, Ahluwalia D, Baker AF, Cranmer LD, Ferraro D, Wang Y, Duan JX, Ammons WS, Curd JG, Matteucci MD, Hart CP. Liu Q, et al. Among authors: hart cp. Cancer Chemother Pharmacol. 2012 Jun;69(6):1487-98. doi: 10.1007/s00280-012-1852-8. Epub 2012 Mar 2. Cancer Chemother Pharmacol. 2012. PMID: 22382881 Free PMC article.

7

Efficacy and safety of the hypoxia-activated prodrug TH-302 in combination with gemcitabine and nab-paclitaxel in human tumor xenograft models of pancreatic cancer.

Sun JD, Liu Q, Ahluwalia D, Li W, Meng F, Wang Y, Bhupathi D, Ruprell AS, Hart CP. Sun JD, et al. Among authors: hart cp. Cancer Biol Ther. 2015;16(3):438-49. doi: 10.1080/15384047.2014.1003005. Cancer Biol Ther. 2015. PMID: 25679067 Free PMC article. Clinical Trial.

8

TH-302 in Combination with Radiotherapy Enhances the Therapeutic Outcome and Is Associated with Pretreatment [18F]HX4 Hypoxia PET Imaging.

Peeters SG, Zegers CM, Biemans R, Lieuwes NG, van Stiphout RG, Yaromina A, Sun JD, Hart CP, Windhorst AD, van Elmpt W, Dubois LJ, Lambin P. Peeters SG, et al. Among authors: hart cp. Clin Cancer Res. 2015 Jul 1;21(13):2984-92. doi: 10.1158/1078-0432.CCR-15-0018. Epub 2015 Mar 24. Clin Cancer Res. 2015. PMID: 25805800

9

Enhancement of hypoxia-activated prodrug TH-302 anti-tumor activity by Chk1 inhibition.

Meng F, Bhupathi D, Sun JD, Liu Q, Ahluwalia D, Wang Y, Matteucci MD, Hart CP. Meng F, et al. Among authors: hart cp. BMC Cancer. 2015 May 21;15:422. doi: 10.1186/s12885-015-1387-6. BMC Cancer. 2015. PMID: 25994202 Free PMC article.

10

Combination treatment with hypoxia-activated prodrug evofosfamide (TH-302) and mTOR inhibitors results in enhanced antitumor efficacy in preclinical renal cell carcinoma models.

Sun JD, Ahluwalia D, Liu Q, Li W, Wang Y, Meng F, Bhupathi D, Matteucci MD, Hart CP. Sun JD, et al. Among authors: hart cp. Am J Cancer Res. 2015 Jun 15;5(7):2139-55. eCollection 2015. Am J Cancer Res. 2015. PMID: 26328245 Free PMC article.

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