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Synthesis and evaluation of CS-2100, a potent, orally active and S1P(3)- sparing S1P(1) agonist.
Nakamura T, Asano M, Sekiguchi Y, Mizuno Y, Tamaki K, Nara F, Kawase Y, Yabe Y, Nakai D, Kamiyama E, Urasaki-Kaneno Y, Shimozato T, Doi-Komuro H, Kagari T, Tomisato W, Inoue R, Nagasaki M, Yuita H, Oguchi-Oshima K, Kaneko R, Nishi T. Nakamura T, et al. Among authors: nakai d. Eur J Med Chem. 2012 May;51:92-8. doi: 10.1016/j.ejmech.2012.02.022. Epub 2012 Feb 25. Eur J Med Chem. 2012. PMID: 22405291
Species differences between rats and primates (humans and monkeys) in complex cleavage pathways of DS-8500a characterized by 14C-ADME studies in humans and monkeys after administration of two radiolabeled compounds and in vitro studies.
Makino C, Watanabe A, Kato M, Shiozawa H, Takakusa H, Nakai D, Honda T, Watanabe N. Makino C, et al. Among authors: nakai d. Drug Metab Pharmacokinet. 2022 Aug;45:100459. doi: 10.1016/j.dmpk.2022.100459. Epub 2022 Mar 19. Drug Metab Pharmacokinet. 2022. PMID: 35716472
73 results