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Replicating adenovirus-simian immunodeficiency virus (SIV) vectors efficiently prime SIV-specific systemic and mucosal immune responses by targeting myeloid dendritic cells and persisting in rectal macrophages, regardless of immunization route.
Patterson LJ, Kuate S, Daltabuit-Test M, Li Q, Xiao P, McKinnon K, DiPasquale J, Cristillo A, Venzon D, Haase A, Robert-Guroff M. Patterson LJ, et al. Clin Vaccine Immunol. 2012 May;19(5):629-37. doi: 10.1128/CVI.00010-12. Epub 2012 Mar 21. Clin Vaccine Immunol. 2012. PMID: 22441384 Free PMC article.
Durable protection of rhesus macaques immunized with a replicating adenovirus-SIV multigene prime/protein boost vaccine regimen against a second SIVmac251 rectal challenge: role of SIV-specific CD8+ T cell responses.
Malkevitch NV, Patterson LJ, Aldrich MK, Wu Y, Venzon D, Florese RH, Kalyanaraman VS, Pal R, Lee EM, Zhao J, Cristillo A, Robert-Guroff M. Malkevitch NV, et al. Virology. 2006 Sep 15;353(1):83-98. doi: 10.1016/j.virol.2006.05.012. Epub 2006 Jun 30. Virology. 2006. PMID: 16814356 Free article.
Comparative evaluation of oral and intranasal priming with replication-competent adenovirus 5 host range mutant (Ad5hr)-simian immunodeficiency virus (SIV) recombinant vaccines on immunogenicity and protective efficacy against SIV(mac251).
Zhou Q, Hidajat R, Peng B, Venzon D, Aldrich MK, Richardson E, Lee EM, Kalyanaraman VS, Grimes G, Gómez-Román VR, Summers LE, Malkevich N, Robert-Guroff M. Zhou Q, et al. Vaccine. 2007 Nov 19;25(47):8021-35. doi: 10.1016/j.vaccine.2007.09.017. Epub 2007 Sep 29. Vaccine. 2007. PMID: 17935840
Sequential priming with simian immunodeficiency virus (SIV) DNA vaccines, with or without encoded cytokines, and a replicating adenovirus-SIV recombinant followed by protein boosting does not control a pathogenic SIVmac251 mucosal challenge.
Demberg T, Boyer JD, Malkevich N, Patterson LJ, Venzon D, Summers EL, Kalisz I, Kalyanaraman VS, Lee EM, Weiner DB, Robert-Guroff M. Demberg T, et al. J Virol. 2008 Nov;82(21):10911-21. doi: 10.1128/JVI.01129-08. Epub 2008 Aug 27. J Virol. 2008. PMID: 18753198 Free PMC article.
259 results