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Reduction of heart failure by pharmacological inhibition or gene deletion of protein tyrosine phosphatase 1B.
Gomez E, Vercauteren M, Kurtz B, Ouvrard-Pascaud A, Mulder P, Henry JP, Besnier M, Waget A, Hooft Van Huijsduijnen R, Tremblay ML, Burcelin R, Thuillez C, Richard V. Gomez E, et al. Among authors: hooft van huijsduijnen r. J Mol Cell Cardiol. 2012 Jun;52(6):1257-64. doi: 10.1016/j.yjmcc.2012.03.003. Epub 2012 Mar 15. J Mol Cell Cardiol. 2012. PMID: 22446161
Protein-tyrosine phosphatase H1 controls growth hormone receptor signaling and systemic growth.
Pilecka I, Patrignani C, Pescini R, Curchod ML, Perrin D, Xue Y, Yasenchak J, Clark A, Magnone MC, Zaratin P, Valenzuela D, Rommel C, Hooft van Huijsduijnen R. Pilecka I, et al. Among authors: hooft van huijsduijnen r. J Biol Chem. 2007 Nov 30;282(48):35405-15. doi: 10.1074/jbc.M705814200. Epub 2007 Oct 4. J Biol Chem. 2007. PMID: 17921143 Free article.
The protein tyrosine phosphatase PTPN4/PTP-MEG1, an enzyme capable of dephosphorylating the TCR ITAMs and regulating NF-kappaB, is dispensable for T cell development and/or T cell effector functions.
Young JA, Becker AM, Medeiros JJ, Shapiro VS, Wang A, Farrar JD, Quill TA, Hooft van Huijsduijnen R, van Oers NS. Young JA, et al. Among authors: van oers ns, hooft van huijsduijnen r. Mol Immunol. 2008 Aug;45(14):3756-66. doi: 10.1016/j.molimm.2008.05.023. Epub 2008 Jul 9. Mol Immunol. 2008. PMID: 18614237 Free PMC article.
Selecting protein tyrosine phosphatases as drug targets.
Hooft van Huijsduijnen R, Bombrun A, Swinnen D. Hooft van Huijsduijnen R, et al. Drug Discov Today. 2002 Oct 1;7(19):1013-9. doi: 10.1016/s1359-6446(02)02438-8. Drug Discov Today. 2002. PMID: 12546919 Review.
GLEPP1/protein-tyrosine phosphatase phi inhibitors block chemotaxis in vitro and in vivo and improve murine ulcerative colitis.
Gobert RP, van den Eijnden M, Szyndralewiez C, Jorand-Lebrun C, Swinnen D, Chen L, Gillieron C, Pixley F, Juillard P, Gerber P, Johnson-Léger C, Halazy S, Camps M, Bombrun A, Shipp M, Vitte PA, Ardissone V, Ferrandi C, Perrin D, Rommel C, Hooft van Huijsduijnen R. Gobert RP, et al. Among authors: hooft van huijsduijnen r, van den eijnden m. J Biol Chem. 2009 Apr 24;284(17):11385-95. doi: 10.1074/jbc.M807241200. Epub 2009 Feb 20. J Biol Chem. 2009. PMID: 19233845 Free PMC article.
89 results