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The nuclear receptor PPAR gamma selectively inhibits Th17 differentiation in a T cell-intrinsic fashion and suppresses CNS autoimmunity.
Klotz L, Burgdorf S, Dani I, Saijo K, Flossdorf J, Hucke S, Alferink J, Nowak N, Beyer M, Mayer G, Langhans B, Klockgether T, Waisman A, Eberl G, Schultze J, Famulok M, Kolanus W, Glass C, Kurts C, Knolle PA. Klotz L, et al. Among authors: hucke s. J Exp Med. 2009 Sep 28;206(10):2079-89. doi: 10.1084/jem.20082771. Epub 2009 Sep 8. J Exp Med. 2009. PMID: 19737866 Free PMC article.
Fingolimod treatment promotes regulatory phenotype and function of B cells.
Grützke B, Hucke S, Gross CC, Herold MV, Posevitz-Fejfar A, Wildemann BT, Kieseier BC, Dehmel T, Wiendl H, Klotz L. Grützke B, et al. Among authors: hucke s. Ann Clin Transl Neurol. 2015 Feb;2(2):119-30. doi: 10.1002/acn3.155. Epub 2015 Jan 16. Ann Clin Transl Neurol. 2015. PMID: 25750917 Free PMC article.
B7-H1 shapes T-cell-mediated brain endothelial cell dysfunction and regional encephalitogenicity in spontaneous CNS autoimmunity.
Klotz L, Kuzmanov I, Hucke S, Gross CC, Posevitz V, Dreykluft A, Schulte-Mecklenbeck A, Janoschka C, Lindner M, Herold M, Schwab N, Ludwig-Portugall I, Kurts C, Meuth SG, Kuhlmann T, Wiendl H. Klotz L, et al. Among authors: hucke s. Proc Natl Acad Sci U S A. 2016 Oct 11;113(41):E6182-E6191. doi: 10.1073/pnas.1601350113. Epub 2016 Sep 26. Proc Natl Acad Sci U S A. 2016. PMID: 27671636 Free PMC article.
19 results