Tagawa Y - Search Results

1

[11C]Flumazenil brain uptake is influenced by the blood-brain barrier efflux transporter P-glycoprotein.

Froklage FE, Syvänen S, Hendrikse NH, Huisman MC, Molthoff CF, Tagawa Y, Reijneveld JC, Heimans JJ, Lammertsma AA, Eriksson J, de Lange EC, Voskuyl RA. Froklage FE, et al. Among authors: tagawa y. EJNMMI Res. 2012 Mar 28;2:12. doi: 10.1186/2191-219X-2-12. EJNMMI Res. 2012. PMID: 22455873 Free PMC article.

2

Altered GABAA receptor density and unaltered blood-brain barrier transport in a kainate model of epilepsy: an in vivo study using 11C-flumazenil and PET.

Syvänen S, Labots M, Tagawa Y, Eriksson J, Windhorst AD, Lammertsma AA, de Lange EC, Voskuyl RA. Syvänen S, et al. Among authors: tagawa y. J Nucl Med. 2012 Dec;53(12):1974-83. doi: 10.2967/jnumed.112.104588. Epub 2012 Nov 9. J Nucl Med. 2012. PMID: 23143088 Free article.

3

Simultaneous in vivo measurements of receptor density and affinity using [11C]flumazenil and positron emission tomography: comparison of full saturation and steady state methods.

Syvänen S, de Lange EC, Tagawa Y, Schenke M, Molthoff CF, Windhorst AD, Lammertsma AA, Voskuyl RA. Syvänen S, et al. Among authors: tagawa y. Neuroimage. 2011 Aug 1;57(3):928-37. doi: 10.1016/j.neuroimage.2011.05.022. Epub 2011 May 14. Neuroimage. 2011. PMID: 21609773

4

Mechanistic Multilayer Quantitative Model for Nonlinear Pharmacokinetics, Target Occupancy and Pharmacodynamics (PK/TO/PD) Relationship of D-Amino Acid Oxidase Inhibitor, TAK-831 in Mice.

Yoneyama T, Sato S, Sykes A, Fradley R, Stafford S, Bechar S, Howley E, Patel T, Tagawa Y, Moriwaki T, Asahi S. Yoneyama T, et al. Among authors: tagawa y. Pharm Res. 2020 Aug 5;37(8):164. doi: 10.1007/s11095-020-02893-x. Pharm Res. 2020. PMID: 32901384 Free PMC article.

5

Pharmacokinetic and pharmacodynamic modeling of hedgehog inhibitor TAK-441 for the inhibition of Gli1 messenger RNA expression and antitumor efficacy in xenografted tumor model mice.

Kogame A, Tagawa Y, Shibata S, Tojo H, Miyamoto M, Tohyama K, Kondo T, Prakash S, Shyu WC, Asahi S. Kogame A, et al. Among authors: tagawa y. Drug Metab Dispos. 2013 Apr;41(4):727-34. doi: 10.1124/dmd.112.049650. Epub 2013 Jan 8. Drug Metab Dispos. 2013. PMID: 23298863

6

The effects of the concentration-dependent erythrocyte distribution of TAK-802, a potent acetylcholinesterase inhibitor, on rat pharmacokinetics.

Kakehi M, Tagawa Y, Goto A, Kondo T, Asahi S. Kakehi M, et al. Among authors: tagawa y. Biopharm Drug Dispos. 2016 Nov;37(8):467-478. doi: 10.1002/bdd.2029. Epub 2016 Sep 26. Biopharm Drug Dispos. 2016. PMID: 27554287

7

Impact of acute fat mobilisation on the pharmacokinetics of the highly fat distributed compound TAK-357, investigated by physiologically based pharmacokinetic (PBPK) modeling and simulation.

Goto A, Tagawa Y, Moriya Y, Sato S, Furukawa Y, Wakabayashi T, Tsukamoto T, DeJongh J, van Steeg TJ, Moriwaki T, Asahi S. Goto A, et al. Among authors: tagawa y. Biopharm Drug Dispos. 2017 Sep;38(6):373-380. doi: 10.1002/bdd.2075. Epub 2017 May 23. Biopharm Drug Dispos. 2017. PMID: 28256717

8

The Enhancement of Subcutaneous First-Pass Metabolism Causes Nonlinear Pharmacokinetics of TAK-448 after a Single Subcutaneous Administration to Rats.

Moriya Y, Kogame A, Tagawa Y, Morohashi A, Kondo T, Asahi S, Benet LZ. Moriya Y, et al. Among authors: tagawa y. Drug Metab Dispos. 2019 Sep;47(9):1004-1012. doi: 10.1124/dmd.119.087148. Epub 2019 Jun 14. Drug Metab Dispos. 2019. PMID: 31201213

9

Pharmacokinetics and Urinary Excretion Mechanism of Orteronel (TAK-700), A Novel 17,20-Lyase Inhibitor, in Animals.

Goto A, Moriya Y, Takeuchi T, Mandai T, Tagawa Y, Kondo T, Asahi S. Goto A, et al. Among authors: tagawa y. Drug Res (Stuttg). 2016 Apr;66(4):217-22. doi: 10.1055/s-0035-1564118. Epub 2015 Sep 29. Drug Res (Stuttg). 2016. PMID: 26418412

10

Pharmacokinetics of TAK-475, a Squalene Synthase Inhibitor, in Rats and Dogs.

Ebihara T, Teshima K, Kondo T, Tagawa Y, Moriwaki T, Asahi S. Ebihara T, et al. Among authors: tagawa y. Drug Res (Stuttg). 2016 Jun;66(6):287-92. doi: 10.1055/s-0035-1569407. Epub 2016 Feb 2. Drug Res (Stuttg). 2016. PMID: 26839207

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