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Microarray and proteomics expression profiling identifies several candidates, including the valosin-containing protein (VCP), involved in regulating high cellular growth rate in production CHO cell lines.
Doolan P, Meleady P, Barron N, Henry M, Gallagher R, Gammell P, Melville M, Sinacore M, McCarthy K, Leonard M, Charlebois T, Clynes M. Doolan P, et al. Among authors: sinacore m. Biotechnol Bioeng. 2010 May 1;106(1):42-56. doi: 10.1002/bit.22670. Biotechnol Bioeng. 2010. PMID: 20091739
CHO DUKX cell lineages preadapted to growth in serum-free suspension culture enable rapid development of cell culture processes for the manufacture of recombinant proteins.
Sinacore MS, Charlebois TS, Harrison S, Brennan S, Richards T, Hamilton M, Scott S, Brodeur S, Oakes P, Leonard M, Switzer M, Anagnostopoulos A, Foster B, Harris A, Jankowski M, Bond M, Martin S, Adamson SR. Sinacore MS, et al. Biotechnol Bioeng. 1996 Nov 20;52(4):518-28. doi: 10.1002/(SICI)1097-0290(19961120)52:4<518::AID-BIT7>3.0.CO;2-S. Biotechnol Bioeng. 1996. PMID: 18629924
14 results