Nakayama S - Search Results

1

Synthesis and SAR of 1,3-thiazolyl thiophene and pyridine derivatives as potent, orally active and S1P₃-sparing S1P₁ agonists.

Asano M, Nakamura T, Sekiguchi Y, Mizuno Y, Yamaguchi T, Tamaki K, Shimozato T, Doi-Komuro H, Kagari T, Tomisato W, Inoue R, Yuita H, Oguchi-Oshima K, Kaneko R, Nara F, Kawase Y, Masubuchi N, Nakayama S, Koga T, Namba E, Nasu H, Nishi T. Asano M, et al. Among authors: nakayama s. Bioorg Med Chem Lett. 2012 May 1;22(9):3083-8. doi: 10.1016/j.bmcl.2012.03.067. Epub 2012 Mar 23. Bioorg Med Chem Lett. 2012. PMID: 22487179

2

Prediction of human plasma concentration-time profiles of monoclonal antibodies from monkey data by a species-invariant time method.

Oitate M, Nakayama S, Ito T, Kurihara A, Okudaira N, Izumi T. Oitate M, et al. Among authors: nakayama s. Drug Metab Pharmacokinet. 2012;27(3):354-9. doi: 10.2133/dmpk.dmpk-11-sh-059. Epub 2011 Dec 6. Drug Metab Pharmacokinet. 2012. PMID: 22146109 Free article.

3

A zone classification system for risk assessment of idiosyncratic drug toxicity using daily dose and covalent binding.

Nakayama S, Atsumi R, Takakusa H, Kobayashi Y, Kurihara A, Nagai Y, Nakai D, Okazaki O. Nakayama S, et al. Drug Metab Dispos. 2009 Sep;37(9):1970-7. doi: 10.1124/dmd.109.027797. Epub 2009 Jun 1. Drug Metab Dispos. 2009. PMID: 19487250

4

Combination of GSH trapping and time-dependent inhibition assays as a predictive method of drugs generating highly reactive metabolites.

Nakayama S, Takakusa H, Watanabe A, Miyaji Y, Suzuki W, Sugiyama D, Shiosakai K, Honda K, Okudaira N, Izumi T, Okazaki O. Nakayama S, et al. Drug Metab Dispos. 2011 Jul;39(7):1247-54. doi: 10.1124/dmd.111.039180. Epub 2011 Apr 5. Drug Metab Dispos. 2011. PMID: 21467212

5

Covalent binding and tissue distribution/retention assessment of drugs associated with idiosyncratic drug toxicity.

Takakusa H, Masumoto H, Yukinaga H, Makino C, Nakayama S, Okazaki O, Sudo K. Takakusa H, et al. Among authors: nakayama s. Drug Metab Dispos. 2008 Sep;36(9):1770-9. doi: 10.1124/dmd.108.021725. Epub 2008 May 28. Drug Metab Dispos. 2008. PMID: 18508880

6

Population pharmacokinetic analysis of quizartinib in patients with newly diagnosed FLT3-internal-tandem-duplication-positive acute myeloid leukemia.

Vaddady P, Glatard A, Smania G, Nakayama S, Inoue H, Kurumaddali A, Abutarif M, Zheng M. Vaddady P, et al. Among authors: nakayama s. Clin Transl Sci. 2024 Dec;17(12):e70074. doi: 10.1111/cts.70074. Clin Transl Sci. 2024. PMID: 39601658 Free PMC article. Clinical Trial.

7

Physiologically Based Pharmacokinetic Absorption Model for Pexidartinib to Evaluate the Impact of Meal Contents and Intake Timing on Drug Exposure.

Nakayama S, Lukacova V, Tanabe S, Watanabe A, Mullin J, Suarez-Sharp S, Shimizu T. Nakayama S, et al. Clin Pharmacol Drug Dev. 2024 Apr;13(4):440-448. doi: 10.1002/cpdd.1385. Epub 2024 Feb 23. Clin Pharmacol Drug Dev. 2024. PMID: 38396317

8

Concentration-QTcF analysis of quizartinib in patients with newly diagnosed FLT3-internal-tandem-duplication-positive acute myeloid leukemia.

Vaddady P, Smania G, Nakayama S, Inoue H, Kurumaddali A, Abutarif M, Zheng M. Vaddady P, et al. Among authors: nakayama s. Clin Transl Sci. 2024 Nov;17(11):e70065. doi: 10.1111/cts.70065. Clin Transl Sci. 2024. PMID: 39533519 Free PMC article. Clinical Trial.

9

Phase 1 study of DS-1205c combined with gefitinib for EGFR mutation-positive non-small cell lung cancer.

Goto K, Shiraishi Y, Murakami H, Horinouchi H, Toyozawa R, Takeda M, Uno M, Crawford N, McGill J, Jimbo T, Ishigami M, Takayama G, Nakayama S, Ohwada S, Nishio M. Goto K, et al. Among authors: nakayama s. Cancer Med. 2023 Mar;12(6):7090-7104. doi: 10.1002/cam4.5508. Epub 2023 Jan 9. Cancer Med. 2023. PMID: 36621830 Free PMC article. Clinical Trial.

10

Association between equivalized annual household income and regular medical visits for hypertensive patients since the COVID-19 outbreak.

Toyama M, Satoh M, Hashimoto H, Iwabe Y, Yagihashi T, Nakayama S, Murakami T, Nakaya N, Metoki H, Hozawa A, Tabuchi T. Toyama M, et al. Among authors: nakayama s. Hypertens Res. 2025 Jan 8. doi: 10.1038/s41440-024-02067-x. Online ahead of print. Hypertens Res. 2025. PMID: 39774308

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