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Page 1
Synthesis and SAR of 1,3-thiazolyl thiophene and pyridine derivatives as potent, orally active and S1P₃-sparing S1P₁ agonists.
Asano M, Nakamura T, Sekiguchi Y, Mizuno Y, Yamaguchi T, Tamaki K, Shimozato T, Doi-Komuro H, Kagari T, Tomisato W, Inoue R, Yuita H, Oguchi-Oshima K, Kaneko R, Nara F, Kawase Y, Masubuchi N, Nakayama S, Koga T, Namba E, Nasu H, Nishi T. Asano M, et al. Among authors: sekiguchi y. Bioorg Med Chem Lett. 2012 May 1;22(9):3083-8. doi: 10.1016/j.bmcl.2012.03.067. Epub 2012 Mar 23. Bioorg Med Chem Lett. 2012. PMID: 22487179
Discovery of CS-2100, a potent, orally active and S1P3-sparing S1P1 agonist.
Nakamura T, Asano M, Sekiguchi Y, Mizuno Y, Tamaki K, Kimura T, Nara F, Kawase Y, Shimozato T, Doi H, Kagari T, Tomisato W, Inoue R, Nagasaki M, Yuita H, Oguchi-Oshima K, Kaneko R, Watanabe N, Abe Y, Nishi T. Nakamura T, et al. Among authors: sekiguchi y. Bioorg Med Chem Lett. 2012 Feb 15;22(4):1788-92. doi: 10.1016/j.bmcl.2011.12.019. Epub 2012 Jan 2. Bioorg Med Chem Lett. 2012. PMID: 22264485
Synthesis and evaluation of CS-2100, a potent, orally active and S1P(3)- sparing S1P(1) agonist.
Nakamura T, Asano M, Sekiguchi Y, Mizuno Y, Tamaki K, Nara F, Kawase Y, Yabe Y, Nakai D, Kamiyama E, Urasaki-Kaneno Y, Shimozato T, Doi-Komuro H, Kagari T, Tomisato W, Inoue R, Nagasaki M, Yuita H, Oguchi-Oshima K, Kaneko R, Nishi T. Nakamura T, et al. Among authors: sekiguchi y. Eur J Med Chem. 2012 May;51:92-8. doi: 10.1016/j.ejmech.2012.02.022. Epub 2012 Feb 25. Eur J Med Chem. 2012. PMID: 22405291
Synthesis and SAR studies of benzyl ether derivatives as potent orally active S1P₁ agonists.
Tsuji T, Suzuki K, Nakamura T, Goto T, Sekiguchi Y, Ikeda T, Fukuda T, Takemoto T, Mizuno Y, Kimura T, Kawase Y, Nara F, Kagari T, Shimozato T, Yahara C, Inaba S, Honda T, Izumi T, Tamura M, Nishi T. Tsuji T, et al. Among authors: sekiguchi y. Bioorg Med Chem. 2014 Aug 1;22(15):4246-56. doi: 10.1016/j.bmc.2014.05.035. Epub 2014 May 24. Bioorg Med Chem. 2014. PMID: 24909680
Pharmacokinetic and Pharmacodynamic Profiles of Glyco-Modified Atrial Natriuretic Peptide Derivatives Synthesized Using Chemo-enzymatic Synthesis Approaches.
Iwamoto M, Yamaguchi T, Sekiguchi Y, Oishi S, Shiiki T, Soma M, Nakamura K, Yoshida M, Chaya H, Mori Y, Miyauchi R, Hasegawa J, Nagayama T, Honda T. Iwamoto M, et al. Among authors: sekiguchi y. Bioconjug Chem. 2018 Aug 15;29(8):2829-2837. doi: 10.1021/acs.bioconjchem.8b00427. Epub 2018 Aug 3. Bioconjug Chem. 2018. PMID: 30107743
A splice-switching oligonucleotide treatment ameliorates glycogen storage disease type 1a in mice with G6PC c.648G>T.
Ito K, Tajima G, Kamisato C, Tsumura M, Iwamoto M, Sekiguchi Y, Numata Y, Watanabe K, Yabe Y, Kanki S, Fujieda Y, Goto K, Sogawa Y, Oitate M, Nagase H, Tsuji S, Nishizawa T, Kakuta M, Masuda T, Onishi Y, Koizumi M, Nakamura H, Okada S, Matsuo M, Takaishi K. Ito K, et al. Among authors: sekiguchi y. J Clin Invest. 2023 Dec 1;133(23):e163464. doi: 10.1172/JCI163464. J Clin Invest. 2023. PMID: 37788110 Free PMC article.
Real-world clinical practice of current periprocedural anticoagulation management in catheter ablation of atrial fibrillation: Data from a large prospective ablation registry.
Taomoto Y, Miyazaki S, Nagata Y, Nitta J, Inaba O, Shirai Y, Tanaka Y, Sekiguchi Y, Inamura Y, Sagawa Y, Mizukami A, Azegami K, Iwai S, Hachiya H, Ono Y, Takahashi A, Sasaki T, Yamauchi Y, Okada H, Suzuki A, Suzuki M, Handa K, Hirao K, Nakajima J, Nishimura T, Tao S, Takigawa M, Sasano T. Taomoto Y, et al. Among authors: sekiguchi y. J Arrhythm. 2025 Jan 14;41(1):e13182. doi: 10.1002/joa3.13182. eCollection 2025 Feb. J Arrhythm. 2025. PMID: 39817001 Free PMC article.
Complete genome sequence of Roseburia faecis M72/1T.
Murotomi K, Tourlousse DM, Hamajima M, Sekiguchi Y. Murotomi K, et al. Among authors: sekiguchi y. Microbiol Resour Announc. 2025 Jan 8:e0125324. doi: 10.1128/mra.01253-24. Online ahead of print. Microbiol Resour Announc. 2025. PMID: 39772859 Free article.
914 results