Koch WJ - Search Results

1

Cardiac G-protein-coupled receptor kinase 2 ablation induces a novel Ca2+ handling phenotype resistant to adverse alterations and remodeling after myocardial infarction.

Raake PW, Zhang X, Vinge LE, Brinks H, Gao E, Jaleel N, Li Y, Tang M, Most P, Dorn GW 2nd, Houser SR, Katus HA, Chen X, Koch WJ. Raake PW, et al. Among authors: koch wj. Circulation. 2012 May 1;125(17):2108-18. doi: 10.1161/CIRCULATIONAHA.111.044255. Epub 2012 Apr 10. Circulation. 2012. PMID: 22496128 Free PMC article.

2

Reciprocal in vivo regulation of myocardial G protein-coupled receptor kinase expression by beta-adrenergic receptor stimulation and blockade.

Iaccarino G, Tomhave ED, Lefkowitz RJ, Koch WJ. Iaccarino G, et al. Among authors: koch wj. Circulation. 1998 Oct 27;98(17):1783-9. doi: 10.1161/01.cir.98.17.1783. Circulation. 1998. PMID: 9788834

3

Enhanced contractility and decreased beta-adrenergic receptor kinase-1 in mice lacking endogenous norepinephrine and epinephrine.

Cho MC, Rao M, Koch WJ, Thomas SA, Palmiter RD, Rockman HA. Cho MC, et al. Among authors: koch wj. Circulation. 1999 May 25;99(20):2702-7. doi: 10.1161/01.cir.99.20.2702. Circulation. 1999. PMID: 10338466

4

Low- and high-level transgenic expression of beta2-adrenergic receptors differentially affect cardiac hypertrophy and function in Galphaq-overexpressing mice.

Dorn GW 2nd, Tepe NM, Lorenz JN, Koch WJ, Liggett SB. Dorn GW 2nd, et al. Among authors: koch wj. Proc Natl Acad Sci U S A. 1999 May 25;96(11):6400-5. doi: 10.1073/pnas.96.11.6400. Proc Natl Acad Sci U S A. 1999. PMID: 10339599 Free PMC article.

5

In vivo inhibition of elevated myocardial beta-adrenergic receptor kinase activity in hybrid transgenic mice restores normal beta-adrenergic signaling and function.

Akhter SA, Eckhart AD, Rockman HA, Shotwell K, Lefkowitz RJ, Koch WJ. Akhter SA, et al. Among authors: koch wj. Circulation. 1999 Aug 10;100(6):648-53. doi: 10.1161/01.cir.100.6.648. Circulation. 1999. PMID: 10441103

6

Overexpression of the cardiac beta(2)-adrenergic receptor and expression of a beta-adrenergic receptor kinase-1 (betaARK1) inhibitor both increase myocardial contractility but have differential effects on susceptibility to ischemic injury.

Cross HR, Steenbergen C, Lefkowitz RJ, Koch WJ, Murphy E. Cross HR, et al. Among authors: koch wj. Circ Res. 1999 Nov 26;85(11):1077-84. doi: 10.1161/01.res.85.11.1077. Circ Res. 1999. PMID: 10571539

7

Hybrid transgenic mice reveal in vivo specificity of G protein-coupled receptor kinases in the heart.

Eckhart AD, Duncan SJ, Penn RB, Benovic JL, Lefkowitz RJ, Koch WJ. Eckhart AD, et al. Among authors: koch wj. Circ Res. 2000 Jan 7-21;86(1):43-50. doi: 10.1161/01.res.86.1.43. Circ Res. 2000. PMID: 10625304

8

Physiological induction of a beta-adrenergic receptor kinase inhibitor transgene preserves ss-adrenergic responsiveness in pressure-overload cardiac hypertrophy.

Manning BS, Shotwell K, Mao L, Rockman HA, Koch WJ. Manning BS, et al. Among authors: koch wj. Circulation. 2000 Nov 28;102(22):2751-7. doi: 10.1161/01.cir.102.22.2751. Circulation. 2000. PMID: 11094043

9

In vivo ventricular gene delivery of a beta-adrenergic receptor kinase inhibitor to the failing heart reverses cardiac dysfunction.

Shah AS, White DC, Emani S, Kypson AP, Lilly RE, Wilson K, Glower DD, Lefkowitz RJ, Koch WJ. Shah AS, et al. Among authors: koch wj. Circulation. 2001 Mar 6;103(9):1311-6. doi: 10.1161/01.cir.103.9.1311. Circulation. 2001. PMID: 11238278

10

Ventricular dysfunction after cardioplegic arrest is improved after myocardial gene transfer of a beta-adrenergic receptor kinase inhibitor.

Tevaearai HT, Eckhart AD, Shotwell KF, Wilson K, Koch WJ. Tevaearai HT, et al. Among authors: koch wj. Circulation. 2001 Oct 23;104(17):2069-74. doi: 10.1161/hc4201.097188. Circulation. 2001. PMID: 11673348

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