Nagaraja V - Search Results

1

Promiscuous restriction is a cellular defense strategy that confers fitness advantage to bacteria.

Vasu K, Nagamalleswari E, Nagaraja V. Vasu K, et al. Among authors: nagaraja v. Proc Natl Acad Sci U S A. 2012 May 15;109(20):E1287-93. doi: 10.1073/pnas.1119226109. Epub 2012 Apr 16. Proc Natl Acad Sci U S A. 2012. PMID: 22509013 Free PMC article.

2

Ca(2+)-mediated site-specific DNA cleavage and suppression of promiscuous activity of KpnI restriction endonuclease.

Chandrashekaran S, Saravanan M, Radha DR, Nagaraja V. Chandrashekaran S, et al. Among authors: nagaraja v. J Biol Chem. 2004 Nov 26;279(48):49736-40. doi: 10.1074/jbc.M409483200. Epub 2004 Sep 16. J Biol Chem. 2004. PMID: 15375161 Free article.

3

R.KpnI, an HNH superfamily REase, exhibits differential discrimination at non-canonical sequences in the presence of Ca2+ and Mg2+.

Saravanan M, Vasu K, Kanakaraj R, Rao DN, Nagaraja V. Saravanan M, et al. Among authors: nagaraja v. Nucleic Acids Res. 2007;35(8):2777-86. doi: 10.1093/nar/gkm114. Epub 2007 Apr 11. Nucleic Acids Res. 2007. PMID: 17430971 Free PMC article.

4

Dual role for Zn2+ in maintaining structural integrity and inducing DNA sequence specificity in a promiscuous endonuclease.

Saravanan M, Vasu K, Ghosh S, Nagaraja V. Saravanan M, et al. Among authors: nagaraja v. J Biol Chem. 2007 Nov 2;282(44):32320-6. doi: 10.1074/jbc.M705927200. Epub 2007 Sep 4. J Biol Chem. 2007. PMID: 17785455 Free article.

5

Structural integrity of the beta beta alpha-Metal finger motif is required for DNA binding and stable protein-DNA complex formation in R.KpnI.

Vasu K, Saravanan M, Bujnicki JM, Nagaraja V. Vasu K, et al. Among authors: nagaraja v. Biochim Biophys Acta. 2008 Feb;1784(2):269-75. doi: 10.1016/j.bbapap.2007.07.011. Biochim Biophys Acta. 2008. PMID: 18329982

6

Evolution of sequence specificity in a restriction endonuclease by a point mutation.

Saravanan M, Vasu K, Nagaraja V. Saravanan M, et al. Among authors: nagaraja v. Proc Natl Acad Sci U S A. 2008 Jul 29;105(30):10344-7. doi: 10.1073/pnas.0804974105. Epub 2008 Jul 22. Proc Natl Acad Sci U S A. 2008. PMID: 18647833 Free PMC article.

7

Generation of a manganese specific restriction endonuclease with nicking activity.

Vasu K, Saravanan M, Rajendra BV, Nagaraja V. Vasu K, et al. Among authors: nagaraja v. Biochemistry. 2010 Sep 28;49(38):8425-33. doi: 10.1021/bi101035k. Biochemistry. 2010. PMID: 20734974

8

Endonuclease active site plasticity allows DNA cleavage with diverse alkaline Earth and transition metal ions.

Vasu K, Saravanan M, Nagaraja V. Vasu K, et al. Among authors: nagaraja v. ACS Chem Biol. 2011 Sep 16;6(9):934-42. doi: 10.1021/cb200107y. Epub 2011 Jul 7. ACS Chem Biol. 2011. PMID: 21736285

9

Ca(2+) binding to the ExDxD motif regulates the DNA cleavage specificity of a promiscuous endonuclease.

Nagamalleswari E, Vasu K, Nagaraja V. Nagamalleswari E, et al. Among authors: nagaraja v. Biochemistry. 2012 Nov 6;51(44):8939-49. doi: 10.1021/bi301151y. Epub 2012 Oct 25. Biochemistry. 2012. PMID: 23072305

10

Diverse functions of restriction-modification systems in addition to cellular defense.

Vasu K, Nagaraja V. Vasu K, et al. Among authors: nagaraja v. Microbiol Mol Biol Rev. 2013 Mar;77(1):53-72. doi: 10.1128/MMBR.00044-12. Microbiol Mol Biol Rev. 2013. PMID: 23471617 Free PMC article. Review.

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