Kwong AD - Search Results

1

Hepatitis C viral evolution in genotype 1 treatment-naïve and treatment-experienced patients receiving telaprevir-based therapy in clinical trials.

Kieffer TL, De Meyer S, Bartels DJ, Sullivan JC, Zhang EZ, Tigges A, Dierynck I, Spanks J, Dorrian J, Jiang M, Adiwijaya B, Ghys A, Beumont M, Kauffman RS, Adda N, Jacobson IM, Sherman KE, Zeuzem S, Kwong AD, Picchio G. Kieffer TL, et al. Among authors: kwong ad. PLoS One. 2012;7(4):e34372. doi: 10.1371/journal.pone.0034372. Epub 2012 Apr 12. PLoS One. 2012. PMID: 22511937 Free PMC article.

2

Telaprevir and pegylated interferon-alpha-2a inhibit wild-type and resistant genotype 1 hepatitis C virus replication in patients.

Kieffer TL, Sarrazin C, Miller JS, Welker MW, Forestier N, Reesink HW, Kwong AD, Zeuzem S. Kieffer TL, et al. Among authors: kwong ad. Hepatology. 2007 Sep;46(3):631-9. doi: 10.1002/hep.21781. Hepatology. 2007. PMID: 17680654 Clinical Trial.

3

Natural prevalence of hepatitis C virus variants with decreased sensitivity to NS3.4A protease inhibitors in treatment-naive subjects.

Bartels DJ, Zhou Y, Zhang EZ, Marcial M, Byrn RA, Pfeiffer T, Tigges AM, Adiwijaya BS, Lin C, Kwong AD, Kieffer TL. Bartels DJ, et al. Among authors: kwong ad. J Infect Dis. 2008 Sep 15;198(6):800-7. doi: 10.1086/591141. J Infect Dis. 2008. PMID: 18637752

4

Viral resistance to specifically targeted antiviral therapies for hepatitis C (STAT-Cs).

Kieffer TL, Kwong AD, Picchio GR. Kieffer TL, et al. Among authors: kwong ad. J Antimicrob Chemother. 2010 Feb;65(2):202-12. doi: 10.1093/jac/dkp388. Epub 2009 Nov 10. J Antimicrob Chemother. 2010. PMID: 19903720 Review.

5

Discovery and development of telaprevir: an NS3-4A protease inhibitor for treating genotype 1 chronic hepatitis C virus.

Kwong AD, Kauffman RS, Hurter P, Mueller P. Kwong AD, et al. Nat Biotechnol. 2011 Nov 8;29(11):993-1003. doi: 10.1038/nbt.2020. Nat Biotechnol. 2011. PMID: 22068541

6

Compensatory substitutions in the HCV NS3/4A protease cleavage sites are not observed in patients treated unsuccessfully with telaprevir combination treatment.

Sullivan JC, Zhang EZ, Bartels DJ, Tigges A, Dorrian JL, Kwong AD, Kieffer TL. Sullivan JC, et al. Among authors: kwong ad. Virol J. 2012 Aug 6;9:147. doi: 10.1186/1743-422X-9-147. Virol J. 2012. PMID: 22866919 Free PMC article.

7

Hepatitis C virus variants with decreased sensitivity to direct-acting antivirals (DAAs) were rarely observed in DAA-naive patients prior to treatment.

Bartels DJ, Sullivan JC, Zhang EZ, Tigges AM, Dorrian JL, De Meyer S, Takemoto D, Dondero E, Kwong AD, Picchio G, Kieffer TL. Bartels DJ, et al. Among authors: kwong ad. J Virol. 2013 Feb;87(3):1544-53. doi: 10.1128/JVI.02294-12. Epub 2012 Nov 14. J Virol. 2013. PMID: 23152524 Free PMC article.

8

A multi-variant, viral dynamic model of genotype 1 HCV to assess the in vivo evolution of protease-inhibitor resistant variants.

Adiwijaya BS, Herrmann E, Hare B, Kieffer T, Lin C, Kwong AD, Garg V, Randle JC, Sarrazin C, Zeuzem S, Caron PR. Adiwijaya BS, et al. Among authors: kwong ad. PLoS Comput Biol. 2010 Apr 15;6(4):e1000745. doi: 10.1371/journal.pcbi.1000745. PLoS Comput Biol. 2010. PMID: 20419154 Free PMC article.

9

Development of a sensitive RT-PCR method for amplifying and sequencing near full-length HCV genotype 1 RNA from patient samples.

Zhang EZ, Bartels DJ, Frantz JD, Seepersaud S, Lippke JA, Shames B, Zhou Y, Lin C, Kwong A, Kieffer TL. Zhang EZ, et al. Virol J. 2013 Feb 12;10:53. doi: 10.1186/1743-422X-10-53. Virol J. 2013. PMID: 23402332 Free PMC article.

10

Phenotypic and structural analyses of hepatitis C virus NS3 protease Arg155 variants: sensitivity to telaprevir (VX-950) and interferon alpha.

Zhou Y, Müh U, Hanzelka BL, Bartels DJ, Wei Y, Rao BG, Brennan DL, Tigges AM, Swenson L, Kwong AD, Lin C. Zhou Y, et al. Among authors: kwong ad. J Biol Chem. 2007 Aug 3;282(31):22619-28. doi: 10.1074/jbc.M610207200. Epub 2007 Jun 6. J Biol Chem. 2007. PMID: 17556358 Free article.

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