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Constitutively active mutant gp130 receptor protein from inflammatory hepatocellular adenoma is inhibited by an anti-gp130 antibody that specifically neutralizes interleukin 11 signaling.
Sommer J, Effenberger T, Volpi E, Waetzig GH, Bernhardt M, Suthaus J, Garbers C, Rose-John S, Floss DM, Scheller J. Sommer J, et al. Among authors: suthaus j. J Biol Chem. 2012 Apr 20;287(17):13743-51. doi: 10.1074/jbc.M111.349167. J Biol Chem. 2012. PMID: 22523320 Free PMC article.
N-linked glycosylation is essential for the stability but not the signaling function of the interleukin-6 signal transducer glycoprotein 130.
Waetzig GH, Chalaris A, Rosenstiel P, Suthaus J, Holland C, Karl N, Vallés Uriarte L, Till A, Scheller J, Grötzinger J, Schreiber S, Rose-John S, Seegert D. Waetzig GH, et al. Among authors: suthaus j. J Biol Chem. 2010 Jan 15;285(3):1781-9. doi: 10.1074/jbc.M109.075952. Epub 2009 Nov 13. J Biol Chem. 2010. PMID: 19915009 Free PMC article.