Muller-Steffner H - Search Results

1

Insights into the mechanism of bovine CD38/NAD+glycohydrolase from the X-ray structures of its Michaelis complex and covalently-trapped intermediates.

Egea PF, Muller-Steffner H, Kuhn I, Cakir-Kiefer C, Oppenheimer NJ, Stroud RM, Kellenberger E, Schuber F. Egea PF, et al. Among authors: muller steffner h. PLoS One. 2012;7(4):e34918. doi: 10.1371/journal.pone.0034918. Epub 2012 Apr 18. PLoS One. 2012. PMID: 22529956 Free PMC article.

2

Probing the catalytic mechanism of bovine CD38/NAD+ glycohydrolase by site directed mutagenesis of key active site residues.

Kuhn I, Kellenberger E, Cakir-Kiefer C, Muller-Steffner H, Schuber F. Kuhn I, et al. Among authors: muller steffner h. Biochim Biophys Acta. 2014 Jul;1844(7):1317-31. doi: 10.1016/j.bbapap.2014.03.014. Epub 2014 Apr 8. Biochim Biophys Acta. 2014. PMID: 24721563

3

Nicotinamide 2-fluoroadenine dinucleotide unmasks the NAD+ glycohydrolase activity of Aplysia californica adenosine 5'-diphosphate ribosyl cyclase.

Zhang B, Muller-Steffner H, Schuber F, Potter BV. Zhang B, et al. Biochemistry. 2007 Apr 3;46(13):4100-9. doi: 10.1021/bi061933w. Epub 2007 Mar 7. Biochemistry. 2007. PMID: 17341094

4

Identification of the N-glycosylation sites on recombinant bovine CD38 expressed in Pichia pastoris: their impact on enzyme stability and catalytic activity.

Muller-Steffner H, Kuhn I, Argentini M, Schuber F. Muller-Steffner H, et al. Protein Expr Purif. 2010 Apr;70(2):151-7. doi: 10.1016/j.pep.2009.10.003. Epub 2009 Oct 7. Protein Expr Purif. 2010. PMID: 19818407

5

Flavonoids as inhibitors of human CD38.

Kellenberger E, Kuhn I, Schuber F, Muller-Steffner H. Kellenberger E, et al. Among authors: muller steffner h. Bioorg Med Chem Lett. 2011 Jul 1;21(13):3939-42. doi: 10.1016/j.bmcl.2011.05.022. Epub 2011 May 14. Bioorg Med Chem Lett. 2011. PMID: 21641214

6

Schistosoma mansoni NAD(+) catabolizing enzyme: identification of key residues in catalysis.

Kuhn I, Kellenberger E, Schuber F, Muller-Steffner H. Kuhn I, et al. Among authors: muller steffner h. Biochim Biophys Acta. 2013 Dec;1834(12):2520-7. doi: 10.1016/j.bbapap.2013.09.002. Epub 2013 Sep 12. Biochim Biophys Acta. 2013. PMID: 24035885

7

Unifying mechanism for Aplysia ADP-ribosyl cyclase and CD38/NAD(+) glycohydrolases.

Cakir-Kiefer C, Muller-Steffner H, Schuber F. Cakir-Kiefer C, et al. Biochem J. 2000 Jul 1;349(Pt 1):203-10. doi: 10.1042/0264-6021:3490203. Biochem J. 2000. PMID: 10861229 Free PMC article.

8

Kinetic competence of the cADP-ribose-CD38 complex as an intermediate in the CD38/NAD+ glycohydrolase-catalysed reactions: implication for CD38 signalling.

Cakir-Kiefer C, Muller-Steffner H, Oppenheimer N, Schuber F. Cakir-Kiefer C, et al. Biochem J. 2001 Sep 1;358(Pt 2):399-406. doi: 10.1042/0264-6021:3580399. Biochem J. 2001. PMID: 11513738 Free PMC article.

9

CD38 induces apoptosis of a murine pro-B leukemic cell line by a tyrosine kinase-dependent but ADP-ribosyl cyclase- and NAD glycohydrolase-independent mechanism.

Lund FE, Muller-Steffner H, Romero-Ramirez H, Moreno-García ME, Partida-Sánchez S, Makris M, Oppenheimer NJ, Santos-Argumedo L, Schuber F. Lund FE, et al. Int Immunol. 2006 Jul;18(7):1029-42. doi: 10.1093/intimm/dxl037. Epub 2006 May 23. Int Immunol. 2006. PMID: 16720618

10

Redesign of Schistosoma mansoni NAD+ catabolizing enzyme: active site H103W mutation restores ADP-ribosyl cyclase activity.

Kuhn I, Kellenberger E, Rognan D, Lund FE, Muller-Steffner H, Schuber F. Kuhn I, et al. Biochemistry. 2006 Oct 3;45(39):11867-78. doi: 10.1021/bi060930g. Biochemistry. 2006. PMID: 17002287 Free PMC article.

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