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811 results

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Discovery and optimization of a series of 3-(3-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amines: orally bioavailable, selective, and potent ATP-independent Akt inhibitors.
Ashwell MA, Lapierre JM, Brassard C, Bresciano K, Bull C, Cornell-Kennon S, Eathiraj S, France DS, Hall T, Hill J, Kelleher E, Khanapurkar S, Kizer D, Koerner S, Link J, Liu Y, Makhija S, Moussa M, Namdev N, Nguyen K, Nicewonger R, Palma R, Szwaya J, Tandon M, Uppalapati U, Vensel D, Volak LP, Volckova E, Westlund N, Wu H, Yang RY, Chan TC. Ashwell MA, et al. Among authors: chan tc. J Med Chem. 2012 Jun 14;55(11):5291-310. doi: 10.1021/jm300276x. Epub 2012 May 31. J Med Chem. 2012. PMID: 22533986
Discovery of a novel mode of protein kinase inhibition characterized by the mechanism of inhibition of human mesenchymal-epithelial transition factor (c-Met) protein autophosphorylation by ARQ 197.
Eathiraj S, Palma R, Volckova E, Hirschi M, France DS, Ashwell MA, Chan TC. Eathiraj S, et al. Among authors: chan tc. J Biol Chem. 2011 Jun 10;286(23):20666-76. doi: 10.1074/jbc.M110.213801. Epub 2011 Mar 24. J Biol Chem. 2011. PMID: 21454604 Free PMC article.
A novel mode of protein kinase inhibition exploiting hydrophobic motifs of autoinhibited kinases: discovery of ATP-independent inhibitors of fibroblast growth factor receptor.
Eathiraj S, Palma R, Hirschi M, Volckova E, Nakuci E, Castro J, Chen CR, Chan TC, France DS, Ashwell MA. Eathiraj S, et al. Among authors: chan tc. J Biol Chem. 2011 Jun 10;286(23):20677-87. doi: 10.1074/jbc.M110.213736. Epub 2011 Mar 24. J Biol Chem. 2011. PMID: 21454610 Free PMC article.
Development and validation of a liquid chromatography-tandem mass spectrometry method for the determination of ARQ 501 (beta-lapachone) in plasma and tumors from nu/nu mouse xenografts.
Savage RE, Hall T, Bresciano K, Bailey J, Starace M, Chan TC. Savage RE, et al. Among authors: chan tc. J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Sep 1;872(1-2):148-53. doi: 10.1016/j.jchromb.2008.07.031. Epub 2008 Jul 31. J Chromatogr B Analyt Technol Biomed Life Sci. 2008. PMID: 18706870
E-box independent chromatin recruitment turns MYOD into a transcriptional repressor.
Nicoletti C, Massenet J, Pintado-Urbanc AP, Connor LJ, Nicolau M, Sundar S, Xu M, Schmitt A, Zhang W, Fang Z, Chan TCI, Tapscott SJ, Cheung TH, Simon MD, Caputo L, Puri PL. Nicoletti C, et al. Among authors: chan tci. bioRxiv [Preprint]. 2024 Dec 5:2024.12.05.627024. doi: 10.1101/2024.12.05.627024. bioRxiv. 2024. PMID: 39677796 Free PMC article. Preprint.
Comparing pharmacists versus allergists in low-risk penicillin allergy delabelling: The Hong Kong Penicillin Allergy Pharmacist Initiative (HK-PAPI).
Hooi JKY, Low MCH, To JCL, Mak HWF, Choi MM, Tam CCP, Mak RWM, Wong VKC, Chan TCC, Li AWT, Mak CCY, Chiang V, Chu GKH, Wong JCY, Li PH. Hooi JKY, et al. Among authors: chan tcc. World Allergy Organ J. 2024 Nov 21;17(12):101003. doi: 10.1016/j.waojou.2024.101003. eCollection 2024 Dec. World Allergy Organ J. 2024. PMID: 39640898 Free PMC article.
811 results