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Small-molecule inducers of insulin expression in pancreatic alpha-cells.
Fomina-Yadlin D, Kubicek S, Walpita D, Dancik V, Hecksher-Sørensen J, Bittker JA, Sharifnia T, Shamji A, Clemons PA, Wagner BK, Schreiber SL. Fomina-Yadlin D, et al. Proc Natl Acad Sci U S A. 2010 Aug 24;107(34):15099-104. doi: 10.1073/pnas.1010018107. Epub 2010 Aug 9. Proc Natl Acad Sci U S A. 2010. PMID: 20696901 Free PMC article.
NAMPT is the cellular target of STF-31-like small-molecule probes.
Adams DJ, Ito D, Rees MG, Seashore-Ludlow B, Puyang X, Ramos AH, Cheah JH, Clemons PA, Warmuth M, Zhu P, Shamji AF, Schreiber SL. Adams DJ, et al. Among authors: shamji af. ACS Chem Biol. 2014 Oct 17;9(10):2247-54. doi: 10.1021/cb500347p. Epub 2014 Aug 7. ACS Chem Biol. 2014. PMID: 25058389 Free PMC article.
Chromatin-targeting small molecules cause class-specific transcriptional changes in pancreatic endocrine cells.
Kubicek S, Gilbert JC, Fomina-Yadlin D, Gitlin AD, Yuan Y, Wagner FF, Holson EB, Luo T, Lewis TA, Taylor B, Gupta S, Shamji AF, Wagner BK, Clemons PA, Schreiber SL. Kubicek S, et al. Among authors: shamji af. Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):5364-9. doi: 10.1073/pnas.1201079109. Epub 2012 Mar 20. Proc Natl Acad Sci U S A. 2012. PMID: 22434908 Free PMC article.
Discovery of small-molecule modulators of the Sonic Hedgehog pathway.
Schaefer GI, Perez JR, Duvall JR, Stanton BZ, Shamji AF, Schreiber SL. Schaefer GI, et al. Among authors: shamji af. J Am Chem Soc. 2013 Jul 3;135(26):9675-80. doi: 10.1021/ja400034k. Epub 2013 Jun 25. J Am Chem Soc. 2013. PMID: 23725514 Free PMC article.
58 results