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Page 1
Single immunization with genetically attenuated Pf∆mei2 (GA2) parasites by mosquito bite in controlled human malaria infection: a placebo-controlled randomized trial.
Roozen GVT, van Schuijlenburg R, Hensen ADO, Koopman JPR, Lamers OAC, Geurten FJA, Sijtsma JC, Baalbergen E, Janse JJ, Chevalley-Maurel S, Naar CM, Bezemer S, Kroeze H, van de Stadt HJF, de Visser B, Meij P, Tihaya MS, Colstrup E, Iliopoulou E, de Bes-Roeleveld HM, Wessels E, van der Stoep MYEC, Janse CJ, Murugan R, Franke-Fayard BMD, Roestenberg M. Roozen GVT, et al. Among authors: sijtsma jc. Nat Med. 2025 Jan 3. doi: 10.1038/s41591-024-03347-2. Online ahead of print. Nat Med. 2025. PMID: 39753962
Clinical tolerance but no protective efficacy in a placebo-controlled trial of repeated controlled schistosome infection.
Koopman JPR, Houlder EL, Janse JJ, Lamers OA, Roozen GV, Sijtsma JC, Casacuberta-Partal M, Hilt ST, van der Stoep MYEC, van Amerongen-Westra IM, Brienen EA, Wammes LJ, van Lieshout L, van Dam GJ, Corstjens PL, van Diepen A, Yazdanbakhsh M, Hokke CH, Roestenberg M. Koopman JPR, et al. Among authors: sijtsma jc. J Clin Invest. 2024 Dec 12:e185422. doi: 10.1172/JCI185422. Online ahead of print. J Clin Invest. 2024. PMID: 39666392 Free article.
Early symptom-associated inflammatory responses shift to type 2 responses in controlled human schistosome infection.
Houlder EL, Stam KA, Koopman JPR, König MH, Langenberg MCC, Hoogerwerf MA, Niewold P, Sonnet F, Janse JJ, Partal MC, Sijtsma JC, de Bes-Roeleveld LHM, Kruize YCM, Yazdanbakhsh M, Roestenberg M. Houlder EL, et al. Among authors: sijtsma jc. Sci Immunol. 2024 Jul 5;9(97):eadl1965. doi: 10.1126/sciimmunol.adl1965. Epub 2024 Jul 5. Sci Immunol. 2024. PMID: 38968336
Ageing of Plasmodium falciparum malaria sporozoites alters their motility, infectivity and reduces immune activation in vitro.
van Schuijlenburg R, Azargoshasb S, de Korne CM, Sijtsma JC, Bezemer S, van der Ham AJ, Baalbergen E, Geurten F, de Bes-Roeleveld LM, Chevalley-Maurel SC, van Oosterom MN, van Leeuwen FWB, Franke-Fayard B, Roestenberg M. van Schuijlenburg R, et al. Among authors: sijtsma jc. Malar J. 2024 Apr 19;23(1):111. doi: 10.1186/s12936-024-04946-7. Malar J. 2024. PMID: 38641838 Free PMC article.
Protective efficacy of short-term infection with Necator americanus hookworm larvae in healthy volunteers in the Netherlands: a single-centre, placebo-controlled, randomised, controlled, phase 1 trial.
Hoogerwerf MA, Janse JJ, Kuiper VP, van Schuijlenburg R, Kruize YC, Sijtsma JC, Nosoh BA, Koopman JR, Verbeek-Menken PH, Westra IM, Meij P, Brienen EA, Visser LG, van Lieshout L, Jochems SP, Yazdanbakhsh M, Roestenberg M. Hoogerwerf MA, et al. Among authors: sijtsma jc. Lancet Microbe. 2023 Dec;4(12):e1024-e1034. doi: 10.1016/S2666-5247(23)00218-5. Lancet Microbe. 2023. PMID: 38042152 Free article. Clinical Trial.
Safety and infectivity of female cercariae in Schistosoma-naïve, healthy participants: a controlled human Schistosoma mansoni infection study.
Koopman JPR, Houlder EL, Janse JJ, Casacuberta-Partal M, Lamers OAC, Sijtsma JC, de Dood C, Hilt ST, Ozir-Fazalalikhan A, Kuiper VP, Roozen GVT, de Bes-Roeleveld LM, Kruize YCM, Wammes LJ, Smits HH, van Lieshout L, van Dam GJ, van Amerongen-Westra IM, Meij P, Corstjens PLAM, Jochems SP, van Diepen A, Yazdanbakhsh M, Hokke CH, Roestenberg M. Koopman JPR, et al. Among authors: sijtsma jc. EBioMedicine. 2023 Nov;97:104832. doi: 10.1016/j.ebiom.2023.104832. Epub 2023 Oct 12. EBioMedicine. 2023. PMID: 37837930 Free PMC article.
Causal chemoprophylactic activity of cabamiquine against Plasmodium falciparum in a controlled human malaria infection: a randomised, double-blind, placebo-controlled study in the Netherlands.
van der Plas JL, Kuiper VP, Bagchus WM, Bödding M, Yalkinoglu Ö, Tappert A, Seitzinger A, Spangenberg T, Bezuidenhout D, Wilkins J, Oeuvray C, Dhingra SK, Thathy V, Fidock DA, Smidt LCA, Roozen GVT, Koopman JPR, Lamers OAC, Sijtsma J, van Schuijlenburg R, Wessels E, Meij P, Kamerling IMC, Roestenberg M, Khandelwal A. van der Plas JL, et al. Among authors: sijtsma j. Lancet Infect Dis. 2023 Oct;23(10):1164-1174. doi: 10.1016/S1473-3099(23)00212-8. Epub 2023 Jul 3. Lancet Infect Dis. 2023. PMID: 37414066 Clinical Trial.
Sporozoite motility as a quantitative readout for anti-CSP antibody inhibition.
de Korne CM, van Schuijlenburg R, Sijtsma JC, de Bes HM, Baalbergen E, Azargoshasb S, van Oosterom MN, McCall MBB, van Leeuwen FWB, Roestenberg M. de Korne CM, et al. Among authors: sijtsma jc. Sci Rep. 2022 Oct 13;12(1):17194. doi: 10.1038/s41598-022-22154-8. Sci Rep. 2022. PMID: 36229488 Free PMC article.
17 results