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A chemocentric approach to the identification of cancer targets.
Flachner B, Lörincz Z, Carotti A, Nicolotti O, Kuchipudi P, Remez N, Sanz F, Tóvári J, Szabó MJ, Bertók B, Cseh S, Mestres J, Dormán G. Flachner B, et al. PLoS One. 2012;7(4):e35582. doi: 10.1371/journal.pone.0035582. Epub 2012 Apr 25. PLoS One. 2012. PMID: 22558171 Free PMC article.
Inhibition of c-Met with the specific small molecule tyrosine kinase inhibitor SU11274 decreases growth and metastasis formation of experimental human melanoma.
Kenessey I, Keszthelyi M, Krámer Z, Berta J, Adám A, Dobos J, Mildner M, Flachner B, Cseh S, Barna G, Szokol B, Orfi L, Kéri G, Döme B, Klepetko W, Tímár J, Tóvári J. Kenessey I, et al. Among authors: flachner b. Curr Cancer Drug Targets. 2010 May;10(3):332-42. doi: 10.2174/156800910791190184. Curr Cancer Drug Targets. 2010. PMID: 20370683
Combination of 2D/3D ligand-based similarity search in rapid virtual screening from multimillion compound repositories. Selection and biological evaluation of potential PDE4 and PDE5 inhibitors.
Dobi K, Hajdú I, Flachner B, Fabó G, Szaszkó M, Bognár M, Magyar C, Simon I, Szisz D, Lőrincz Z, Cseh S, Dormán G. Dobi K, et al. Among authors: flachner b. Molecules. 2014 May 28;19(6):7008-39. doi: 10.3390/molecules19067008. Molecules. 2014. PMID: 24879613 Free PMC article.
Combination of Pharmacophore Matching, 2D Similarity Search, and In Vitro Biological Assays in the Selection of Potential 5-HT6 Antagonists from Large Commercial Repositories.
Dobi K, Flachner B, Pukáncsik M, Máthé E, Bognár M, Szaszkó M, Magyar C, Hajdú I, Lőrincz Z, Simon I, Fülöp F, Cseh S, Dormán G. Dobi K, et al. Among authors: flachner b. Chem Biol Drug Des. 2015 Oct;86(4):864-80. doi: 10.1111/cbdd.12563. Epub 2015 Apr 30. Chem Biol Drug Des. 2015. PMID: 25823681
Design and Selection of Novel C1s Inhibitors by In Silico and In Vitro Approaches.
Szilágyi K, Hajdú I, Flachner B, Lőrincz Z, Balczer J, Gál P, Závodszky P, Pirli C, Balogh B, Mándity IM, Cseh S, Dormán G. Szilágyi K, et al. Among authors: flachner b. Molecules. 2019 Oct 9;24(20):3641. doi: 10.3390/molecules24203641. Molecules. 2019. PMID: 31600984 Free PMC article.
24 results