Strongin AY - Search Results

1

New details of HCV NS3/4A proteinase functionality revealed by a high-throughput cleavage assay.

Shiryaev SA, Thomsen ER, Cieplak P, Chudin E, Cheltsov AV, Chee MS, Kozlov IA, Strongin AY. Shiryaev SA, et al. Among authors: strongin ay. PLoS One. 2012;7(4):e35759. doi: 10.1371/journal.pone.0035759. Epub 2012 Apr 27. PLoS One. 2012. PMID: 22558217 Free PMC article.

2

Cleavage preference distinguishes the two-component NS2B-NS3 serine proteinases of Dengue and West Nile viruses.

Shiryaev SA, Kozlov IA, Ratnikov BI, Smith JW, Lebl M, Strongin AY. Shiryaev SA, et al. Among authors: strongin ay. Biochem J. 2007 Feb 1;401(3):743-52. doi: 10.1042/BJ20061136. Biochem J. 2007. PMID: 17067286 Free PMC article.

3

Switching the substrate specificity of the two-component NS2B-NS3 flavivirus proteinase by structure-based mutagenesis.

Shiryaev SA, Ratnikov BI, Aleshin AE, Kozlov IA, Nelson NA, Lebl M, Smith JW, Liddington RC, Strongin AY. Shiryaev SA, et al. Among authors: strongin ay. J Virol. 2007 May;81(9):4501-9. doi: 10.1128/JVI.02719-06. Epub 2007 Feb 14. J Virol. 2007. PMID: 17301157 Free PMC article.

4

Virtual ligand screening of the National Cancer Institute (NCI) compound library leads to the allosteric inhibitory scaffolds of the West Nile Virus NS3 proteinase.

Shiryaev SA, Cheltsov AV, Gawlik K, Ratnikov BI, Strongin AY. Shiryaev SA, et al. Among authors: strongin ay. Assay Drug Dev Technol. 2011 Feb;9(1):69-78. doi: 10.1089/adt.2010.0309. Epub 2010 Nov 4. Assay Drug Dev Technol. 2011. PMID: 21050032 Free PMC article.

5

Probing of exosites leads to novel inhibitor scaffolds of HCV NS3/4A proteinase.

Shiryaev SA, Cheltsov AV, Strongin AY. Shiryaev SA, et al. Among authors: strongin ay. PLoS One. 2012;7(7):e40029. doi: 10.1371/journal.pone.0040029. Epub 2012 Jul 2. PLoS One. 2012. PMID: 22768327 Free PMC article.

6

High-resolution analysis and functional mapping of cleavage sites and substrate proteins of furin in the human proteome.

Shiryaev SA, Chernov AV, Golubkov VS, Thomsen ER, Chudin E, Chee MS, Kozlov IA, Strongin AY, Cieplak P. Shiryaev SA, et al. Among authors: strongin ay. PLoS One. 2013;8(1):e54290. doi: 10.1371/journal.pone.0054290. Epub 2013 Jan 15. PLoS One. 2013. PMID: 23335997 Free PMC article.

7

High-Throughput Multiplexed Peptide-Centric Profiling Illustrates Both Substrate Cleavage Redundancy and Specificity in the MMP Family.

Kukreja M, Shiryaev SA, Cieplak P, Muranaka N, Routenberg DA, Chernov AV, Kumar S, Remacle AG, Smith JW, Kozlov IA, Strongin AY. Kukreja M, et al. Among authors: strongin ay. Chem Biol. 2015 Aug 20;22(8):1122-33. doi: 10.1016/j.chembiol.2015.07.008. Epub 2015 Aug 6. Chem Biol. 2015. PMID: 26256476 Free PMC article.

8

Cleavage targets and the D-arginine-based inhibitors of the West Nile virus NS3 processing proteinase.

Shiryaev SA, Ratnikov BI, Chekanov AV, Sikora S, Rozanov DV, Godzik A, Wang J, Smith JW, Huang Z, Lindberg I, Samuel MA, Diamond MS, Strongin AY. Shiryaev SA, et al. Among authors: strongin ay. Biochem J. 2006 Jan 15;393(Pt 2):503-11. doi: 10.1042/BJ20051374. Biochem J. 2006. PMID: 16229682 Free PMC article.

9

Expression and purification of a two-component flaviviral proteinase resistant to autocleavage at the NS2B-NS3 junction region.

Shiryaev SA, Aleshin AE, Ratnikov BI, Smith JW, Liddington RC, Strongin AY. Shiryaev SA, et al. Among authors: strongin ay. Protein Expr Purif. 2007 Apr;52(2):334-9. doi: 10.1016/j.pep.2006.11.009. Epub 2006 Dec 1. Protein Expr Purif. 2007. PMID: 17189703 Free PMC article.

10

Structural evidence for regulation and specificity of flaviviral proteases and evolution of the Flaviviridae fold.

Aleshin AE, Shiryaev SA, Strongin AY, Liddington RC. Aleshin AE, et al. Among authors: strongin ay. Protein Sci. 2007 May;16(5):795-806. doi: 10.1110/ps.072753207. Epub 2007 Mar 30. Protein Sci. 2007. PMID: 17400917 Free PMC article.

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