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167 results

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Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency.
McAfee Q, Zhang Z, Samanta A, Levi SM, Ma XH, Piao S, Lynch JP, Uehara T, Sepulveda AR, Davis LE, Winkler JD, Amaravadi RK. McAfee Q, et al. Among authors: amaravadi rk. Proc Natl Acad Sci U S A. 2012 May 22;109(21):8253-8. doi: 10.1073/pnas.1118193109. Epub 2012 May 7. Proc Natl Acad Sci U S A. 2012. PMID: 22566612 Free PMC article.
Cancer. Autophagy in tumor immunity.
Amaravadi RK. Amaravadi RK. Science. 2011 Dec 16;334(6062):1501-2. doi: 10.1126/science.1216428. Science. 2011. PMID: 22174234 No abstract available.
Lys05: a new lysosomal autophagy inhibitor.
Amaravadi RK, Winkler JD. Amaravadi RK, et al. Autophagy. 2012 Sep;8(9):1383-4. doi: 10.4161/auto.20958. Epub 2012 Aug 10. Autophagy. 2012. PMID: 22878685 Free PMC article.
Autophagy and tumor cell invasion.
Amaravadi RK. Amaravadi RK. Cell Cycle. 2012 Oct 15;11(20):3718-9. doi: 10.4161/cc.22147. Epub 2012 Sep 14. Cell Cycle. 2012. PMID: 22982997 Free PMC article. No abstract available.
Autophagy: a targetable linchpin of cancer cell metabolism.
Leone RD, Amaravadi RK. Leone RD, et al. Among authors: amaravadi rk. Trends Endocrinol Metab. 2013 Apr;24(4):209-17. doi: 10.1016/j.tem.2013.01.008. Epub 2013 Mar 6. Trends Endocrinol Metab. 2013. PMID: 23474062 Free PMC article. Review.
Targeting ER stress-induced autophagy overcomes BRAF inhibitor resistance in melanoma.
Ma XH, Piao SF, Dey S, McAfee Q, Karakousis G, Villanueva J, Hart LS, Levi S, Hu J, Zhang G, Lazova R, Klump V, Pawelek JM, Xu X, Xu W, Schuchter LM, Davies MA, Herlyn M, Winkler J, Koumenis C, Amaravadi RK. Ma XH, et al. Among authors: amaravadi rk. J Clin Invest. 2014 Mar;124(3):1406-17. doi: 10.1172/JCI70454. Epub 2014 Feb 24. J Clin Invest. 2014. PMID: 24569374 Free PMC article.
Combined autophagy and proteasome inhibition: a phase 1 trial of hydroxychloroquine and bortezomib in patients with relapsed/refractory myeloma.
Vogl DT, Stadtmauer EA, Tan KS, Heitjan DF, Davis LE, Pontiggia L, Rangwala R, Piao S, Chang YC, Scott EC, Paul TM, Nichols CW, Porter DL, Kaplan J, Mallon G, Bradner JE, Amaravadi RK. Vogl DT, et al. Among authors: amaravadi rk. Autophagy. 2014 Aug;10(8):1380-90. doi: 10.4161/auto.29264. Epub 2014 May 20. Autophagy. 2014. PMID: 24991834 Free PMC article. Clinical Trial.
167 results