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Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency.
McAfee Q, Zhang Z, Samanta A, Levi SM, Ma XH, Piao S, Lynch JP, Uehara T, Sepulveda AR, Davis LE, Winkler JD, Amaravadi RK. McAfee Q, et al. Among authors: sepulveda ar. Proc Natl Acad Sci U S A. 2012 May 22;109(21):8253-8. doi: 10.1073/pnas.1118193109. Epub 2012 May 7. Proc Natl Acad Sci U S A. 2012. PMID: 22566612 Free PMC article.
Multiple Gastrointestinal Polyps in Patients Treated with BRAF Inhibitors.
Amaravadi RK, Hamilton KE, Ma X, Piao S, Portillo AD, Nathanson KL, Carlino MS, Long GV, Puzanov I, Xu X, Morrissette JJ, Tsai KY, Flaherty KT, Sosman JA, Goodman GR, McArthur GA, Rustgi AK, Metz DC, Schuchter LM, Chapman PB, Sepulveda AR. Amaravadi RK, et al. Among authors: sepulveda ar. Clin Cancer Res. 2015 Dec 1;21(23):5215-21. doi: 10.1158/1078-0432.CCR-15-0469. Epub 2015 Jul 22. Clin Cancer Res. 2015. PMID: 26202952 Free PMC article.
Evaluation of Mutational Testing of Preneoplastic Barrett's Mucosa by Next-Generation Sequencing of Formalin-Fixed, Paraffin-Embedded Endoscopic Samples for Detection of Concurrent Dysplasia and Adenocarcinoma in Barrett's Esophagus.
Del Portillo A, Lagana SM, Yao Y, Uehara T, Jhala N, Ganguly T, Nagy P, Gutierrez J, Luna A, Abrams J, Liu Y, Brand R, Sepulveda JL, Falk GW, Sepulveda AR. Del Portillo A, et al. Among authors: sepulveda jl, sepulveda ar. J Mol Diagn. 2015 Jul;17(4):412-9. doi: 10.1016/j.jmoldx.2015.02.006. Epub 2015 Jun 8. J Mol Diagn. 2015. PMID: 26068095 Free PMC article.
LIN28B promotes colon cancer progression and metastasis.
King CE, Cuatrecasas M, Castells A, Sepulveda AR, Lee JS, Rustgi AK. King CE, et al. Among authors: sepulveda ar. Cancer Res. 2011 Jun 15;71(12):4260-8. doi: 10.1158/0008-5472.CAN-10-4637. Epub 2011 Apr 21. Cancer Res. 2011. PMID: 21512136 Free PMC article.
A precision oncology approach to the pharmacological targeting of mechanistic dependencies in neuroendocrine tumors.
Alvarez MJ, Subramaniam PS, Tang LH, Grunn A, Aburi M, Rieckhof G, Komissarova EV, Hagan EA, Bodei L, Clemons PA, Dela Cruz FS, Dhall D, Diolaiti D, Fraker DA, Ghavami A, Kaemmerer D, Karan C, Kidd M, Kim KM, Kim HC, Kunju LP, Langel Ü, Li Z, Lee J, Li H, LiVolsi V, Pfragner R, Rainey AR, Realubit RB, Remotti H, Regberg J, Roses R, Rustgi A, Sepulveda AR, Serra S, Shi C, Yuan X, Barberis M, Bergamaschi R, Chinnaiyan AM, Detre T, Ezzat S, Frilling A, Hommann M, Jaeger D, Kim MK, Knudsen BS, Kung AL, Leahy E, Metz DC, Milsom JW, Park YS, Reidy-Lagunes D, Schreiber S, Washington K, Wiedenmann B, Modlin I, Califano A. Alvarez MJ, et al. Among authors: sepulveda ar. Nat Genet. 2018 Jul;50(7):979-989. doi: 10.1038/s41588-018-0138-4. Epub 2018 Jun 18. Nat Genet. 2018. PMID: 29915428 Free PMC article.
214 results