Sluis-Cremer N - Search Results

1

Frequent emergence of N348I in HIV-1 subtype C reverse transcriptase with failure of initial therapy reduces susceptibility to reverse-transcriptase inhibitors.

Brehm JH, Koontz DL, Wallis CL, Shutt KA, Sanne I, Wood R, McIntyre JA, Stevens WS, Sluis-Cremer N, Mellors JW; CIPRA-SA Project 1 Study Team. Brehm JH, et al. Clin Infect Dis. 2012 Sep;55(5):737-45. doi: 10.1093/cid/cis501. Epub 2012 May 22. Clin Infect Dis. 2012. PMID: 22618567 Free PMC article. Clinical Trial.

2

Destabilization of the HIV-1 reverse transcriptase dimer upon interaction with N-acyl hydrazone inhibitors.

Sluis-Cremer N, Arion D, Parniak MA. Sluis-Cremer N, et al. Mol Pharmacol. 2002 Aug;62(2):398-405. doi: 10.1124/mol.62.2.398. Mol Pharmacol. 2002. PMID: 12130693

3

Structure-activity relationships in HIV-1 reverse transcriptase revealed by radiation target analysis.

Sluis-Cremer N, Kempner E, Parniak MA. Sluis-Cremer N, et al. Protein Sci. 2003 Sep;12(9):2081-6. doi: 10.1110/ps.03130503. Protein Sci. 2003. PMID: 12931006 Free PMC article.

4

Conformational changes in HIV-1 reverse transcriptase induced by nonnucleoside reverse transcriptase inhibitor binding.

Sluis-Cremer N, Temiz NA, Bahar I. Sluis-Cremer N, et al. Curr HIV Res. 2004 Oct;2(4):323-32. doi: 10.2174/1570162043351093. Curr HIV Res. 2004. PMID: 15544453 Free PMC article. Review.

5

Stereo-selectivity of HIV-1 reverse transcriptase toward isomers of thymidine-5'-O-1-thiotriphosphate.

Radzio J, Sluis-Cremer N. Radzio J, et al. Protein Sci. 2005 Jul;14(7):1929-33. doi: 10.1110/ps.051445605. Epub 2005 Jun 3. Protein Sci. 2005. PMID: 15937285 Free PMC article.

6

The 3'-azido group is not the primary determinant of 3'-azido-3'-deoxythymidine (AZT) responsible for the excision phenotype of AZT-resistant HIV-1.

Sluis-Cremer N, Arion D, Parikh U, Koontz D, Schinazi RF, Mellors JW, Parniak MA. Sluis-Cremer N, et al. J Biol Chem. 2005 Aug 12;280(32):29047-52. doi: 10.1074/jbc.M503166200. Epub 2005 Jun 20. J Biol Chem. 2005. PMID: 15970587 Free article.

7

Molecular mechanism by which the K70E mutation in human immunodeficiency virus type 1 reverse transcriptase confers resistance to nucleoside reverse transcriptase inhibitors.

Sluis-Cremer N, Sheen CW, Zelina S, Torres PS, Parikh UM, Mellors JW. Sluis-Cremer N, et al. Antimicrob Agents Chemother. 2007 Jan;51(1):48-53. doi: 10.1128/AAC.00683-06. Epub 2006 Nov 6. Antimicrob Agents Chemother. 2007. PMID: 17088490 Free PMC article.

8

Selection of mutations in the connection and RNase H domains of human immunodeficiency virus type 1 reverse transcriptase that increase resistance to 3'-azido-3'-dideoxythymidine.

Brehm JH, Koontz D, Meteer JD, Pathak V, Sluis-Cremer N, Mellors JW. Brehm JH, et al. J Virol. 2007 Aug;81(15):7852-9. doi: 10.1128/JVI.02203-06. Epub 2007 May 16. J Virol. 2007. PMID: 17507476 Free PMC article.

9

Molecular mechanisms of bidirectional antagonism between K65R and thymidine analog mutations in HIV-1 reverse transcriptase.

Parikh UM, Zelina S, Sluis-Cremer N, Mellors JW. Parikh UM, et al. AIDS. 2007 Jul 11;21(11):1405-14. doi: 10.1097/QAD.0b013e3281ac229b. AIDS. 2007. PMID: 17589186

10

Probing nonnucleoside inhibitor-induced active-site distortion in HIV-1 reverse transcriptase by transient kinetic analyses.

Xia Q, Radzio J, Anderson KS, Sluis-Cremer N. Xia Q, et al. Protein Sci. 2007 Aug;16(8):1728-37. doi: 10.1110/ps.072829007. Protein Sci. 2007. PMID: 17656585 Free PMC article.

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