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Alpha-synuclein aggregation involves a bafilomycin A 1-sensitive autophagy pathway.
Klucken J, Poehler AM, Ebrahimi-Fakhari D, Schneider J, Nuber S, Rockenstein E, Schlötzer-Schrehardt U, Hyman BT, McLean PJ, Masliah E, Winkler J. Klucken J, et al. Among authors: nuber s. Autophagy. 2012 May 1;8(5):754-66. doi: 10.4161/auto.19371. Epub 2012 May 1. Autophagy. 2012. PMID: 22647715 Free PMC article.
Severely impaired hippocampal neurogenesis associates with an early serotonergic deficit in a BAC α-synuclein transgenic rat model of Parkinson's disease.
Kohl Z, Ben Abdallah N, Vogelgsang J, Tischer L, Deusser J, Amato D, Anderson S, Müller CP, Riess O, Masliah E, Nuber S, Winkler J. Kohl Z, et al. Among authors: nuber s. Neurobiol Dis. 2016 Jan;85:206-217. doi: 10.1016/j.nbd.2015.10.021. Epub 2015 Oct 30. Neurobiol Dis. 2016. PMID: 26523794 Free PMC article.
Overexpression of synphilin-1 promotes clearance of soluble and misfolded alpha-synuclein without restoring the motor phenotype in aged A30P transgenic mice.
Casadei N, Pöhler AM, Tomás-Zapico C, Torres-Peraza J, Schwedhelm I, Witz A, Zamolo I, De Heer R, Spruijt B, Noldus LP, Klucken J, Lucas JJ, Kahle PJ, Krüger R, Riess O, Nuber S. Casadei N, et al. Among authors: nuber s. Hum Mol Genet. 2014 Feb 1;23(3):767-81. doi: 10.1093/hmg/ddt467. Epub 2013 Sep 24. Hum Mol Genet. 2014. PMID: 24064336
Overexpression of the calpain-specific inhibitor calpastatin reduces human alpha-Synuclein processing, aggregation and synaptic impairment in [A30P]αSyn transgenic mice.
Diepenbroek M, Casadei N, Esmer H, Saido TC, Takano J, Kahle PJ, Nixon RA, Rao MV, Melki R, Pieri L, Helling S, Marcus K, Krueger R, Masliah E, Riess O, Nuber S. Diepenbroek M, et al. Among authors: nuber s. Hum Mol Genet. 2014 Aug 1;23(15):3975-89. doi: 10.1093/hmg/ddu112. Epub 2014 Mar 11. Hum Mol Genet. 2014. PMID: 24619358 Free PMC article.
61 results