Chen S - Search Results

1

Caspase-6 activity in a BACHD mouse modulates steady-state levels of mutant huntingtin protein but is not necessary for production of a 586 amino acid proteolytic fragment.

Gafni J, Papanikolaou T, Degiacomo F, Holcomb J, Chen S, Menalled L, Kudwa A, Fitzpatrick J, Miller S, Ramboz S, Tuunanen PI, Lehtimäki KK, Yang XW, Park L, Kwak S, Howland D, Park H, Ellerby LM. Gafni J, et al. Among authors: chen s. J Neurosci. 2012 May 30;32(22):7454-65. doi: 10.1523/JNEUROSCI.6379-11.2012. J Neurosci. 2012. PMID: 22649225 Free PMC article.

2

Posttranslational modification of ataxin-7 at lysine 257 prevents autophagy-mediated turnover of an N-terminal caspase-7 cleavage fragment.

Mookerjee S, Papanikolaou T, Guyenet SJ, Sampath V, Lin A, Vitelli C, DeGiacomo F, Sopher BL, Chen SF, La Spada AR, Ellerby LM. Mookerjee S, et al. Among authors: chen sf. J Neurosci. 2009 Dec 2;29(48):15134-44. doi: 10.1523/JNEUROSCI.4720-09.2009. J Neurosci. 2009. PMID: 19955365 Free PMC article.

3

Integration-independent Transgenic Huntington Disease Fragment Mouse Models Reveal Distinct Phenotypes and Life Span in Vivo.

O'Brien R, DeGiacomo F, Holcomb J, Bonner A, Ring KL, Zhang N, Zafar K, Weiss A, Lager B, Schilling B, Gibson BW, Chen S, Kwak S, Ellerby LM. O'Brien R, et al. Among authors: chen s. J Biol Chem. 2015 Jul 31;290(31):19287-306. doi: 10.1074/jbc.M114.623561. Epub 2015 May 29. J Biol Chem. 2015. PMID: 26025364 Free PMC article.

4

Proteolytic cleavage of ataxin-7 by caspase-7 modulates cellular toxicity and transcriptional dysregulation.

Young JE, Gouw L, Propp S, Sopher BL, Taylor J, Lin A, Hermel E, Logvinova A, Chen SF, Chen S, Bredesen DE, Truant R, Ptacek LJ, La Spada AR, Ellerby LM. Young JE, et al. Among authors: chen sf, chen s. J Biol Chem. 2007 Oct 12;282(41):30150-60. doi: 10.1074/jbc.M705265200. Epub 2007 Jul 23. J Biol Chem. 2007. PMID: 17646170 Free article.

5

Calpain-1 cleaves and activates caspase-7.

Gafni J, Cong X, Chen SF, Gibson BW, Ellerby LM. Gafni J, et al. J Biol Chem. 2009 Sep 11;284(37):25441-9. doi: 10.1074/jbc.M109.038174. Epub 2009 Jul 18. J Biol Chem. 2009. PMID: 19617626 Free PMC article.

6

Proteolytic cleavage of ataxin-7 promotes SCA7 retinal degeneration and neurological dysfunction.

Guyenet SJ, Mookerjee SS, Lin A, Custer SK, Chen SF, Sopher BL, La Spada AR, Ellerby LM. Guyenet SJ, et al. Among authors: chen sf. Hum Mol Genet. 2015 Jul 15;24(14):3908-17. doi: 10.1093/hmg/ddv121. Epub 2015 Apr 9. Hum Mol Genet. 2015. PMID: 25859008 Free PMC article.

7

Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease.

Hermel E, Gafni J, Propp SS, Leavitt BR, Wellington CL, Young JE, Hackam AS, Logvinova AV, Peel AL, Chen SF, Hook V, Singaraja R, Krajewski S, Goldsmith PC, Ellerby HM, Hayden MR, Bredesen DE, Ellerby LM. Hermel E, et al. Among authors: chen sf. Cell Death Differ. 2004 Apr;11(4):424-38. doi: 10.1038/sj.cdd.4401358. Cell Death Differ. 2004. PMID: 14713958

8

FGF-2 promotes neurogenesis and neuroprotection and prolongs survival in a transgenic mouse model of Huntington's disease.

Jin K, LaFevre-Bernt M, Sun Y, Chen S, Gafni J, Crippen D, Logvinova A, Ross CA, Greenberg DA, Ellerby LM. Jin K, et al. Among authors: chen s. Proc Natl Acad Sci U S A. 2005 Dec 13;102(50):18189-94. doi: 10.1073/pnas.0506375102. Epub 2005 Dec 2. Proc Natl Acad Sci U S A. 2005. PMID: 16326808 Free PMC article.

9

Mitochondrial-dependent Ca2+ handling in Huntington's disease striatal cells: effect of histone deacetylase inhibitors.

Oliveira JM, Chen S, Almeida S, Riley R, Gonçalves J, Oliveira CR, Hayden MR, Nicholls DG, Ellerby LM, Rego AC. Oliveira JM, et al. Among authors: chen s. J Neurosci. 2006 Oct 25;26(43):11174-86. doi: 10.1523/JNEUROSCI.3004-06.2006. J Neurosci. 2006. PMID: 17065457 Free PMC article.

10

Mitochondrial dysfunction in Huntington's disease: the bioenergetics of isolated and in situ mitochondria from transgenic mice.

Oliveira JM, Jekabsons MB, Chen S, Lin A, Rego AC, Gonçalves J, Ellerby LM, Nicholls DG. Oliveira JM, et al. Among authors: chen s. J Neurochem. 2007 Apr;101(1):241-9. doi: 10.1111/j.1471-4159.2006.04361.x. J Neurochem. 2007. PMID: 17394466 Free article.

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