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A novel yeast cell-based screen identifies flavone as a tankyrase inhibitor.
Yashiroda Y, Okamoto R, Hatsugai K, Takemoto Y, Goshima N, Saito T, Hamamoto M, Sugimoto Y, Osada H, Seimiya H, Yoshida M. Yashiroda Y, et al. Among authors: saito t. Biochem Biophys Res Commun. 2010 Apr 9;394(3):569-73. doi: 10.1016/j.bbrc.2010.03.021. Epub 2010 Mar 7. Biochem Biophys Res Commun. 2010. PMID: 20214890
Limonoid compounds inhibit sphingomyelin biosynthesis by preventing CERT protein-dependent extraction of ceramides from the endoplasmic reticulum.
Hullin-Matsuda F, Tomishige N, Sakai S, Ishitsuka R, Ishii K, Makino A, Greimel P, Abe M, Laviad EL, Lagarde M, Vidal H, Saito T, Osada H, Hanada K, Futerman AH, Kobayashi T. Hullin-Matsuda F, et al. Among authors: saito t. J Biol Chem. 2012 Jul 13;287(29):24397-411. doi: 10.1074/jbc.M112.344432. Epub 2012 May 17. J Biol Chem. 2012. PMID: 22605339 Free PMC article.
Screening of a virtual mirror-image library of natural products.
Noguchi T, Oishi S, Honda K, Kondoh Y, Saito T, Ohno H, Osada H, Fujii N. Noguchi T, et al. Among authors: saito t. Chem Commun (Camb). 2016 Jun 8;52(49):7653-6. doi: 10.1039/c6cc03114e. Chem Commun (Camb). 2016. PMID: 27198617
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