Gerrard JA - Search Results

1

Structural and dynamic requirements for optimal activity of the essential bacterial enzyme dihydrodipicolinate synthase.

Reboul CF, Porebski BT, Griffin MD, Dobson RC, Perugini MA, Gerrard JA, Buckle AM. Reboul CF, et al. Among authors: gerrard ja. PLoS Comput Biol. 2012;8(6):e1002537. doi: 10.1371/journal.pcbi.1002537. Epub 2012 Jun 7. PLoS Comput Biol. 2012. PMID: 22685390 Free PMC article.

2

The preparation of (S)-aspartate semi-aldehyde appropriate for use in biochemical studies.

Roberts SJ, Morris JC, Dobson RC, Gerrard JA. Roberts SJ, et al. Among authors: gerrard ja. Bioorg Med Chem Lett. 2003 Jan 20;13(2):265-7. doi: 10.1016/s0960-894x(02)00923-x. Bioorg Med Chem Lett. 2003. PMID: 12482436

3

Dihydrodipicolinate synthase is not inhibited by its substrate, (S)-aspartate beta-semialdehyde.

Dobson RC, Gerrard JA, Pearce FG. Dobson RC, et al. Among authors: gerrard ja. Biochem J. 2004 Feb 1;377(Pt 3):757-62. doi: 10.1042/BJ20031389. Biochem J. 2004. PMID: 14580236 Free PMC article.

4

The crystal structure of three site-directed mutants of Escherichia coli dihydrodipicolinate synthase: further evidence for a catalytic triad.

Dobson RC, Valegård K, Gerrard JA. Dobson RC, et al. Among authors: gerrard ja. J Mol Biol. 2004 Apr 23;338(2):329-39. doi: 10.1016/j.jmb.2004.02.060. J Mol Biol. 2004. PMID: 15066435

5

Dihydrodipicolinate synthase (DHDPS) from Escherichia coli displays partial mixed inhibition with respect to its first substrate, pyruvate.

Dobson RC, Griffin MD, Roberts SJ, Gerrard JA. Dobson RC, et al. Among authors: gerrard ja. Biochimie. 2004 Apr-May;86(4-5):311-5. doi: 10.1016/j.biochi.2004.03.008. Biochimie. 2004. PMID: 15194235

6

Two new irreversible inhibitors of dihydrodipicolinate synthase: diethyl (E,E)-4-oxo-2,5-heptadienedioate and diethyl (E)-4-oxo-2-heptenedioate.

Turner JJ, Healy JP, Dobson RC, Gerrard JA, Hutton CA. Turner JJ, et al. Among authors: gerrard ja. Bioorg Med Chem Lett. 2005 Feb 15;15(4):995-8. doi: 10.1016/j.bmcl.2004.12.043. Bioorg Med Chem Lett. 2005. PMID: 15686899

7

Insight into the self-association of key enzymes from pathogenic species.

Perugini MA, Griffin MD, Smith BJ, Webb LE, Davis AJ, Handman E, Gerrard JA. Perugini MA, et al. Among authors: gerrard ja. Eur Biophys J. 2005 Jul;34(5):469-76. doi: 10.1007/s00249-005-0491-y. Epub 2005 Jun 25. Eur Biophys J. 2005. PMID: 15981001

8

The crystal structures of native and (S)-lysine-bound dihydrodipicolinate synthase from Escherichia coli with improved resolution show new features of biological significance.

Dobson RC, Griffin MD, Jameson GB, Gerrard JA. Dobson RC, et al. Among authors: gerrard ja. Acta Crystallogr D Biol Crystallogr. 2005 Aug;61(Pt 8):1116-24. doi: 10.1107/S0907444905016318. Epub 2005 Jul 20. Acta Crystallogr D Biol Crystallogr. 2005. PMID: 16041077

9

Role of arginine 138 in the catalysis and regulation of Escherichia coli dihydrodipicolinate synthase.

Dobson RC, Devenish SR, Turner LA, Clifford VR, Pearce FG, Jameson GB, Gerrard JA. Dobson RC, et al. Among authors: gerrard ja. Biochemistry. 2005 Oct 4;44(39):13007-13. doi: 10.1021/bi051281w. Biochemistry. 2005. PMID: 16185069

10

Dihydrodipicolinate synthase from Thermotoga maritima.

Pearce FG, Perugini MA, McKerchar HJ, Gerrard JA. Pearce FG, et al. Among authors: gerrard ja. Biochem J. 2006 Dec 1;400(2):359-66. doi: 10.1042/BJ20060771. Biochem J. 2006. PMID: 16872276 Free PMC article.

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