Handzlik J - Search Results

1

Synthesis and SAR-study for novel arylpiperazine derivatives of 5-arylidenehydantoin with α₁-adrenoceptor antagonistic properties.

Handzlik J, Szymańska E, Wójcik R, Dela A, Jastrzębska-Więsek M, Karolak-Wojciechowska J, Fruziński A, Siwek A, Filipek B, Kieć-Kononowicz K. Handzlik J, et al. Bioorg Med Chem. 2012 Jul 15;20(14):4245-57. doi: 10.1016/j.bmc.2012.05.064. Epub 2012 Jun 5. Bioorg Med Chem. 2012. PMID: 22739084

2

Synthesis and evaluation of in vivo activity of diphenylhydantoin basic derivatives.

Dylag T, Zygmunt M, Maciag D, Handzlik J, Bednarski M, Filipek B, Kieć-Kononowicz K. Dylag T, et al. Among authors: handzlik j. Eur J Med Chem. 2004 Dec;39(12):1013-27. doi: 10.1016/j.ejmech.2004.05.008. Eur J Med Chem. 2004. PMID: 15571863

3

Synthesis, alpha 1-adrenoceptor antagonist activity, and SAR study of novel arylpiperazine derivatives of phenytoin.

Handzlik J, Maciag D, Kubacka M, Mogilski S, Filipek B, Stadnicka K, Kieć-Kononowicz K. Handzlik J, et al. Bioorg Med Chem. 2008 Jun 1;16(11):5982-98. doi: 10.1016/j.bmc.2008.04.058. Epub 2008 Apr 26. Bioorg Med Chem. 2008. PMID: 18490167

4

Search for influence of spatial properties on affinity at α1-adrenoceptor subtypes for phenylpiperazine derivatives of phenytoin.

Handzlik J, Pertz HH, Görnemann T, Jähnichen S, Kieć-Kononowicz K. Handzlik J, et al. Bioorg Med Chem Lett. 2010 Oct 15;20(20):6152-6. doi: 10.1016/j.bmcl.2010.07.101. Epub 2010 Jul 30. Bioorg Med Chem Lett. 2010. PMID: 20813529

5

Biological activity of hydantoin derivatives on P-glycoprotein (ABCB1) of mouse lymphoma cells.

Spengler G, Evaristo M, Handzlik J, Serly J, Molnár J, Viveiros M, Kiéc-Kononowicz K, Amaral L. Spengler G, et al. Among authors: handzlik j. Anticancer Res. 2010 Dec;30(12):4867-71. Anticancer Res. 2010. PMID: 21187464

6

Pharmacophore models based studies on the affinity and selectivity toward 5-HT1A with reference to α1-adrenergic receptors among arylpiperazine derivatives of phenytoin.

Handzlik J, Szymańska E, Nędza K, Kubacka M, Siwek A, Mogilski S, Handzlik J, Filipek B, Kieć-Kononowicz K. Handzlik J, et al. Bioorg Med Chem. 2011 Feb 1;19(3):1349-60. doi: 10.1016/j.bmc.2010.11.051. Epub 2010 Dec 5. Bioorg Med Chem. 2011. PMID: 21232965

7

N-Alkenyl and cycloalkyl carbamates as dual acting histamine H3 and H4 receptor ligands.

Więcek M, Kottke T, Ligneau X, Schunack W, Seifert R, Stark H, Handzlik J, Kieć-Kononowicz K. Więcek M, et al. Among authors: handzlik j. Bioorg Med Chem. 2011 May 1;19(9):2850-8. doi: 10.1016/j.bmc.2011.03.046. Epub 2011 Mar 24. Bioorg Med Chem. 2011. PMID: 21498080

8

Synthesis and biological activity of tricyclic cycloalkylimidazo-, pyrimido- and diazepinopurinediones.

Drabczyńska A, Yuzlenko O, Köse M, Paskaleva M, Schiedel AC, Karolak-Wojciechowska J, Handzlik J, Karcz T, Kuder K, Müller CE, Kieć-Kononowicz K. Drabczyńska A, et al. Among authors: handzlik j. Eur J Med Chem. 2011 Sep;46(9):3590-607. doi: 10.1016/j.ejmech.2011.05.023. Epub 2011 May 23. Eur J Med Chem. 2011. PMID: 21664729

9

Amine-alkyl derivatives of hydantoin: new tool to combat resistant bacteria.

Handzlik J, Szymańska E, Chevalier J, Otrębska E, Kieć-Kononowicz K, Pagès JM, Alibert S. Handzlik J, et al. Eur J Med Chem. 2011 Dec;46(12):5807-16. doi: 10.1016/j.ejmech.2011.09.032. Epub 2011 Oct 1. Eur J Med Chem. 2011. PMID: 22000919

10

The activity of 16 new hydantoin compounds on the intrinsic and overexpressed efflux pump system of Staphylococcus aureus.

Dymek A, Armada A, Handzlik J, Viveiros M, Spengler G, Molnar J, Kieć-Kononowicz K, Amaral L. Dymek A, et al. Among authors: handzlik j. In Vivo. 2012 Mar-Apr;26(2):223-9. In Vivo. 2012. PMID: 22351662

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