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The effects of heparins on the liver: application of mechanistic serum biomarkers in a randomized study in healthy volunteers.
Harrill AH, Roach J, Fier I, Eaddy JS, Kurtz CL, Antoine DJ, Spencer DM, Kishimoto TK, Pisetsky DS, Park BK, Watkins PB. Harrill AH, et al. Among authors: watkins pb. Clin Pharmacol Ther. 2012 Aug;92(2):214-20. doi: 10.1038/clpt.2012.40. Epub 2012 Jun 27. Clin Pharmacol Ther. 2012. PMID: 22739141 Free PMC article. Clinical Trial.
Mouse population-guided resequencing reveals that variants in CD44 contribute to acetaminophen-induced liver injury in humans.
Harrill AH, Watkins PB, Su S, Ross PK, Harbourt DE, Stylianou IM, Boorman GA, Russo MW, Sackler RS, Harris SC, Smith PC, Tennant R, Bogue M, Paigen K, Harris C, Contractor T, Wiltshire T, Rusyn I, Threadgill DW. Harrill AH, et al. Among authors: watkins pb. Genome Res. 2009 Sep;19(9):1507-15. doi: 10.1101/gr.090241.108. Epub 2009 May 5. Genome Res. 2009. PMID: 19416960 Free PMC article.
In vitro to in vivo extrapolation and species response comparisons for drug-induced liver injury (DILI) using DILIsym™: a mechanistic, mathematical model of DILI.
Howell BA, Yang Y, Kumar R, Woodhead JL, Harrill AH, Clewell HJ 3rd, Andersen ME, Siler SQ, Watkins PB. Howell BA, et al. Among authors: watkins pb. J Pharmacokinet Pharmacodyn. 2012 Oct;39(5):527-41. doi: 10.1007/s10928-012-9266-0. Epub 2012 Aug 9. J Pharmacokinet Pharmacodyn. 2012. PMID: 22875368
Keratin-18 and microRNA-122 complement alanine aminotransferase as novel safety biomarkers for drug-induced liver injury in two human cohorts.
Thulin P, Nordahl G, Gry M, Yimer G, Aklillu E, Makonnen E, Aderaye G, Lindquist L, Mattsson CM, Ekblom B, Antoine DJ, Park BK, Linder S, Harrill AH, Watkins PB, Glinghammar B, Schuppe-Koistinen I. Thulin P, et al. Among authors: watkins pb. Liver Int. 2014 Mar;34(3):367-78. doi: 10.1111/liv.12322. Epub 2013 Oct 14. Liver Int. 2014. PMID: 24118944
271 results