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HIV-1 reverse transcriptase (RT) polymorphism 172K suppresses the effect of clinically relevant drug resistance mutations to both nucleoside and non-nucleoside RT inhibitors.
Hachiya A, Marchand B, Kirby KA, Michailidis E, Tu X, Palczewski K, Ong YT, Li Z, Griffin DT, Schuckmann MM, Tanuma J, Oka S, Singh K, Kodama EN, Sarafianos SG. Hachiya A, et al. Among authors: oka s. J Biol Chem. 2012 Aug 24;287(35):29988-99. doi: 10.1074/jbc.M112.351551. Epub 2012 Jul 2. J Biol Chem. 2012. PMID: 22761416 Free PMC article.
HLA-Cw8 primarily associated with hypersensitivity to nevirapine.
Gatanaga H, Yazaki H, Tanuma J, Honda M, Genka I, Teruya K, Tachikawa N, Kikuchi Y, Oka S. Gatanaga H, et al. Among authors: oka s. AIDS. 2007 Jan 11;21(2):264-5. doi: 10.1097/QAD.0b013e32801199d9. AIDS. 2007. PMID: 17197830 No abstract available.
Amino acid mutation N348I in the connection subdomain of human immunodeficiency virus type 1 reverse transcriptase confers multiclass resistance to nucleoside and nonnucleoside reverse transcriptase inhibitors.
Hachiya A, Kodama EN, Sarafianos SG, Schuckmann MM, Sakagami Y, Matsuoka M, Takiguchi M, Gatanaga H, Oka S. Hachiya A, et al. Among authors: oka s. J Virol. 2008 Apr;82(7):3261-70. doi: 10.1128/JVI.01154-07. Epub 2008 Jan 23. J Virol. 2008. PMID: 18216099 Free PMC article.
2,649 results