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The epoxyketone-based proteasome inhibitors carfilzomib and orally bioavailable oprozomib have anti-resorptive and bone-anabolic activity in addition to anti-myeloma effects.
Hurchla MA, Garcia-Gomez A, Hornick MC, Ocio EM, Li A, Blanco JF, Collins L, Kirk CJ, Piwnica-Worms D, Vij R, Tomasson MH, Pandiella A, San Miguel JF, Garayoa M, Weilbaecher KN. Hurchla MA, et al. Among authors: tomasson mh. Leukemia. 2013 Feb;27(2):430-40. doi: 10.1038/leu.2012.183. Epub 2012 Jul 5. Leukemia. 2013. PMID: 22763387 Free PMC article.
Platelet and osteoclast beta3 integrins are critical for bone metastasis.
Bakewell SJ, Nestor P, Prasad S, Tomasson MH, Dowland N, Mehrotra M, Scarborough R, Kanter J, Abe K, Phillips D, Weilbaecher KN. Bakewell SJ, et al. Among authors: tomasson mh. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14205-10. doi: 10.1073/pnas.2234372100. Epub 2003 Nov 11. Proc Natl Acad Sci U S A. 2003. PMID: 14612570 Free PMC article.
A randomized double-blind trial of hydroxychloroquine for the prevention of chronic graft-versus-host disease after allogeneic peripheral blood stem cell transplantation.
Fong T, Trinkaus K, Adkins D, Vij R, Devine SM, Tomasson M, Goodnough LT, Lopez S, Graubert T, Shenoy S, Dipersio JF, Khoury HJ. Fong T, et al. Biol Blood Marrow Transplant. 2007 Oct;13(10):1201-6. doi: 10.1016/j.bbmt.2007.06.012. Biol Blood Marrow Transplant. 2007. PMID: 17889357 Free article. Clinical Trial.
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